Objective
Double-strand breaks (DSB) constantly challenge the integrity of the cellular genome and are important contributors to cancer and genetic diseases. Repair of damaged DNA is a dynamic process that requires careful orchestration of a multitude of enzymes and chromatin constituents that are organized into centers (foci). The outgoing laboratory recently developed powerful methods to explore the dynamics of focus assembly/disassembly in vivo. Using these techniques, I will explore one of the most intriguing steps of homologous recombination: the search for homology. During homologous recombination, the broken DNA searches for intact homologous dsDNA within the entire genome. To elucidate when and how the process of homology search occurs in vivo, I will visualise the movement of a donor and an acceptor sequence, as well as recombination factors, before, during and after double strand break repair. I will take advantage of the elegant yeast genetic system and explore the effects of targeted mutations in key enzymes involved in this process. In the return laboratory, I will to transpose the assay developed in the outgoing laboratory in mammalian cells. With the aid of the Marie Curie fellowship, I propose to spend my post-doctoral period to evolve from single molecule approaches in vitro to genetics and in vivo systems involving multiprotein complexes.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences genetics mutation
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics genomes
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IOF-2008
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75230 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.