Objective
A fundamental question in cell biology is how cells determine their shape. Each life form is surrounded by boundary layers that protect, communicate with the environment, and may confer shape and rigidity. However, little is known about the mechanisms determining cell shape, and the broader questions concerning morphogenesis are the same in prokaryotic and eukaryotic systems. How is cell shape regulated temporally and spatially? How is structural information acquired and maintained? In bacteria, the tough external peptidoglycan cell wall is known to be a primary determinant of cell shape. But despite decades of studies, both its ultra-structure and the molecular mechanisms that control wall morphogenesis are poorly understood. A radical change recently occurs with the discovery of a bacterial actin-like cytoskeleton as a primary determinant of cell wall biogenesis. Moreover, actin homologues (MreB family) are not only involved in cell morphogenesis but also in DNA segregation and cell polarity, suggesting a key function in cell development. However, the mechanistic details and the effectors used by MreB proteins to fulfil these roles remain to be elucidated. The general aims of this project are to elucidate the factors controlling bacterial cell wall morphogenesis and to determine the different functions of the bacterial cytoskeleton and the mechanisms underlying them. For this, an interdisciplinary approach combining the methods of genetic, microscopy, biochemistry, physico-chemistry and mathematical modelling will be used.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences physical sciences optics microscopy
- natural sciences biological sciences cell biology cell polarity
- natural sciences mathematics applied mathematics mathematical model
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-RG
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75007 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.