Objective
A highly tumourigenic subpopulation of cancer cells has recently been identified in primary and metastastatic breast cancer. This minority of cells termed tumour-initiating cells or “cancer stem cells“ (CSC) has been shown in several solid tumours to bear stem cell features such as the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumour. Correlating with this, several pathways and genes required for normal stem-cell function are activated in cancer cells and play essential roles in tumourigenesis. However, the specific molecular mechanisms through which CSCs exert their tumourigenic effects remain unknown. The TGF-beta pathway is a key player in mammalian biology, and its misregulation can result in tumour development. Increasing evidences are starting to elucidate the mechanistic basis and clinical relevance of TGF-beta’s role in cancer, yet its complex and pleiotropic nature requires still a much profound understanding of the pathway. The proposed project aims to study a yet unidentified role of TGF-beta in breast cancer stem cell regulation by analyzing human breast cancer cell lines as well as fresh breast tissue samples derived from primary tumours and malignant pleural effusions from patients with breast cancer of diverse grade and stage. TGF-beta regulation of the different subtypes of breast progenitor cells will be assess by colony forming cell and mammosphere-initiating cells assays as well as by an innovative xenotransplantation assay in vitro and in vivo respectively. Moreover, a transcriptomic approach will be designed to discern the mechanisms and molecular determinants of TGF-beta's role in breast stem cell regulation. By developing this project, we will decipher how TGF-beta regulates breast stem/progenitor cell functions, paving the way for a better understanding of its complexity and therapeutic potential.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine oncology breast cancer
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IEF-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
E20 1JQ LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.