Objective
Neurodegenerative disorders such as Alzehimer´s or Parkinson´s affect millions of people in Europe and are linked to the misfolding and aggregation of proteins in the form of amyloid fibrils. The molecular pathways of amyloid aggregation are complex and poorly understood, and involve the population of oligomeric intermediates before fibrils form. Little is known about the role in vivo of amyloid intermediates, despite generally recognized as the major neurotoxic agents. The challenge of this project is to bridge the gap between structural and functional studies of amyloid intermediates, and to rationalize the role of protein-associated factors in amyloid toxicity. I intend to provide new experimental evidence into the causes of conformation-dependent neurotoxicity for the protein alpha-synuclein, the amyloid culprit of Parkinson’s disease. I will identify cellular factors associated with amyloid intermediates by employing mass spectrometry techniques. A protein interaction map for such amyloid species will be created based on the proteins identified. This protein network will provide a pathological atlas of the cellular pathways affected upon amyloid formation. Selected protein targets of the oligomeric intermediates will be characterized structurally, with the aim of identifying structural determinants of amyloid toxicity, the so-called amyloid hot spots. State of the art biophysical methodologies, such as NMR, fluorescence spectroscopy and microscopy will be employed, all of them available at the host institution. Finally, computational modeling of protein-protein interactions will support the experimental work, another major expertise of the host laboratory. It is foreseen that such amyloid hot spots will naturally become targets for therapeutic intervention. Accordingly, the present proposal will have impact on both basic and translational research in Parkinson’s disease.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences physical sciences optics spectroscopy emission spectroscopy
- natural sciences physical sciences optics microscopy
- medical and health sciences basic medicine neurology parkinson
- natural sciences chemical sciences analytical chemistry mass spectrometry
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IEF-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
08028 Barcelona
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.