Objective
The last years have seen an extraordinary explosion of studies characterizing genome variation at different levels, and have opened new opportunities in deciphering the genetic basis of phenotypic characteristics and the evolutionary forces involved. One of the major breakthroughs has been the discovery of an unprecedented degree of structural variation in the human genome, including deletions, duplications and inversions. However, the main challenge is to understand the biological significance of these genomic changes. In particular, for many years inversions have been the paradigm of evolutionary biology. Thus, the identification of the whole set of human inversions gives us a unique opportunity to investigate the functional and evolutionary consequences of this type of changes at a large scale. The specific objectives of the project are: (1) Catalogue the precise location of all common polymorphic inversions in the human genome; (2) Determine the population distribution and the evolutionary history of these inversions; (3) Investigate the functional consequences and the effects on gene expression of human inversions; and (4) Assess the effect of inversions on nucleotide variation patterns and the role of natural selection in their maintenance. This project will follow a multidisciplinary approach that combines experimental and bioinformatic analyses and will benefit from the great amount of information on the human genome already available and that will be generated in the next months. The proposed research therefore represents a very appropriate and timely contribution to the study of human structural variation and its role in phenotypic variation and evolution. Furthermore, it will provide additional insights on genome function, gene-expression regulation mechanisms, and the association of genetic changes and particular traits, and promises to stir novel hypothesis for future studies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- humanities history and archaeology history
- natural sciences biological sciences evolutionary biology
- natural sciences mathematics pure mathematics mathematical analysis functional analysis
- natural sciences biological sciences genetics nucleotides
- natural sciences biological sciences genetics genomes
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2009-StG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
08193 Cerdanyola Del Valles
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.