Objective
The process of adaptation to novel environments is of extraordinary importance to understand the existence of biological diversity. The development of a theory of adaptation during the last 150 years identified natural selection as its cause, and the conditions under which it depends on the existence of the heritable variation encoded in DNA sequences, introduced in finite populations by mutation, recombination and migration. Despite the considerable knowledge about the mechanism of evolution, an understanding of genetic basis of adaptation remains both a theoretical and an empirical challenge. In this project we propose to conduct an unprecedented large scale evolution experiment with the androdioecious nematode Caenorhabditis elegans, under varying levels of outcrossing rates, initial standing genetic variation and frequency of environmental change. With the integration of information from several levels of structural organization, from fitness-proxy and life-history phenotypes to genome wide RNA expression, it will be possible to determine the several genetic and environmental components of diversity. Furthermore, we will perform whole genome linkage disequilibrium (LD) association mapping with experimental evolution, thus determining at the DNA sequence level how the genome is organized and how it feeds back into the population genetic dynamics. Tests of evolutionary theory will be conducted with the data collected. Directional natural selection is expected to maintain genotype diversity, when there are non-linear interactions among several loci. But predominantly stabilizing selection will erode this genetic diversity. While in the first scenario outcrossing will be favoured, in the second it will be a hindrance to adaptation. After an initial characterization, we will work with ~90 populations and measure >104 phenotypes. For mapping we will assay an estimated 106 genotypes. Most of the analytical tools have already been developed.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences genetics mutation
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2009-StG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
75230 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.