Visualization of Dendritic cell IL-12 production and engagement with antigen-specific T cells during Mycobacterium tuberculosis infection in vivo

Projektinformationen

DC-MTB INTERACTIONS

ID Finanzhilfevereinbarung: 247684

Abgeschlossenes Projekt

Startdatum 1 Januar 2010

Enddatum 31 Dezember 2013

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 100 000,00

EU-Beitrag € 100 000,00

Koordiniert durch

KAROLINSKA INSTITUTET
Sweden

Ziel

Mycobacterium tuberculosis (Mtb) is a major pathogen that continues to trouble mankind and puzzle immunologists. There is today a growing need for a better understanding of Mtb infection. Dendritic cells (DC) are unique in that they both prime T cells and through IL-12 production direct their differentiation into anti-mycobacterial effector cells. So studying DC and IL-12 during infection has direct implications for improving our fundamental grasp of immunity to this pathogen. DC-T cell contacts occur in the lymph node (LN). However, if and where DC produce IL-12 in vivo remains unknown. In fact, most of the data on DC responses to Mtb comes from in vitro studies that fail to consider the microenvironment of the LN and its constraints on cell-cell and cell-pathogen interactions. The questions herein address the spatiotemporal regulation of mycobacterial antigen acquisition and IL-12 production by DC and whether they give rise to antigen-specific interactions with T cells that dictate effector function generation. These questions remain at large due to methodological impediments. Visualization techniques provide a valuable insight into the complex in situ interplay between DC, Mtb and T cells that governs the host-pathogen standoff. Improvements in imaging now permit the undertaking of these studies in full dynamic view. Visualizing these vital interactions offer new perspectives into understanding and thus manipulating DC for immunotherapy and vaccination benefits.

Wissenschaftliches Gebiet

• medical and health sciences › clinical medicine › pneumology › tuberculosis
• medical and health sciences › basic medicine › immunology › immunotherapy

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-2009-RG - Marie Curie Action: "Reintegration Grants"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2009-RG
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IRG - International Re-integration Grants (IRG)

Koordinator

KAROLINSKA INSTITUTET

Kontakt Verwaltung

Markus Maeurer (Prof.)

• EU-Beitrag: € 100 000,00
• Adresse: Nobels Vag 5 ; 17177 Stockholm ; Schweden
• Region: Östra Sverige › Stockholm › Stockholms län
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten