Objective
Two severe primary immunodeficiencies; Wiskott-Aldrich syndrome (WAS) and X-linked neutropenia (XLN), are caused by mutations in the same gene encoding the WAS protein (WASP). WASP is a hematopoietic cell-specific cytoskeletal regulator that coordinates receptor signalling to changes in the actin cytokeleton, thereby altering migratory, adhesive, phagocytic, and signalling responses. WAS is caused by loss-of-function mutations in WASP. WAS patients and WASP-deficient mice are immuno-compromised, fail to respond to foreign pathogens, and are prone to develop eczema and autoimmune disease. In contrast, XLN is caused by gain-of-function mutations that lead to a constitutively-active WASP. XLN patients suffer from severe congenital neutropenia. It remains unknown how different mutations in WASP can induce vastly diverse clinical phenotypes. I hypothesize that similar to WASP deficiency, XLN-WASP mutations may affect hematopoietic cells broadly. Moreover, I hypothesize that altered tolerance to self leads to induction of eczema and autoimmunity in WAS patients and WASP-deficient mice. I propose; AIM 1: To reveal the underlying cause for development of XLN by usage of a novel mouse model that I generated during my postdoctoral work. We will determine how XLN-WASP influences the immune response, induces neutropenia, and tumour transformation. AIM 2: To investigate how WAS patients and WASP-deficient mice that fail to respond to foreign pathogens still react vigorously to self and develop eczema and autoimmunity. This project is carried out as a multidisciplinary and translational collaboration together with my postdoctoral mentors in the USA, and researchers in Italy, England, and Sweden. The long-term goal with the project is to increase the mobility of European researchers and the European excellence by defining future targets for therapeutic intervention and to understand the requirement of WASP and the actin cytoskeleton for correct function of hematopoietic cells.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine dermatology
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine immunology autoimmune diseases
- natural sciences biological sciences genetics mutation
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-RG
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
171 77 STOCKHOLM
Sweden
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