Objective
The project seeks to advance our knowledge of the innate immune system at two different but complementary levels, sensing and regulation of signalling. The first aim is centred on danger signals, and how they activate the immune system. We propose to use high-throughput RNA sequencing, molecular biology, fly and bacterial genetics to investigate the global network of genes and pathways that are involved in either endogenous (DNA and chromatin components) or exogenous (pathogen virulence factors) danger signal sensing. Drosophila is used here as a model system to analyse the complexities of host-pathogen interactions. As many bacteria use a common set of virulence factors to target different hosts, this work should lead to the identification of new defence genes and mechanisms in human. The second aim seeks to understand the mechanisms that fine-tune NF-ºB signalling in Drosophila and in mammals. NF-ºB mediates every aspect of inflammation and immune response through transcriptional programs that have to be orchestrated by yet unknown regulatory layers. The ability to effectively target inflammatory diseases for therapeutic intervention requires knowledge of the intricacies of these regulatory layers. First, we propose to characterize the molecular function of a new modulator of NF-ºB signalling that we have recently discovered, by using yeast two-hybrid screens, mass spectrometry and Drosophila genetics. In parallel, we propose to analyze the role of newly discovered and evolutionary conserved small RNAs in the regulation of the innate immune response in Drosophila. This exciting new area of research should lead to a better understanding of the control of immune reactions, one of the most important goals for medical research in the next decade.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences health sciences inflammatory diseases
- medical and health sciences basic medicine immunology
- natural sciences biological sciences genetics RNA
- natural sciences chemical sciences analytical chemistry mass spectrometry
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2009-AdG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.