Community Research and Development Information Service - CORDIS

FP7 APatHome

AP@home

Project ID: 247138
Funded under

Bringing the artificial pancreas home

From 2010-02-01 to 2014-10-31, closed project | AP@home Website

Project details

Total cost:

EUR 13 639 751

EU contribution:

EUR 10 499 851

Coordinated in:

Germany

Call for proposal:

FP7-ICT-2009-4See other projects for this call

Funding scheme:

CP - Collaborative project (generic)

Description

In order to improve treatment of diabetes patients at home, the main goal of <a href="mailto:AP@Home">AP@Home</a> is to build and evaluate an artificial pancreas (AP). The AP will allow automated glucose control: It monitors your blood glucose (sugar) levels and a software algorithm calculates how much insulin to deliver at any time via a built-in insulin infusion pump.

Normally, insulin is given either by injections or via continuous infusion pumps. However, blood glucose levels can be greatly affected by many factors such as diet, physical activity, illness and stress so that it is difficult for patients to judge how much insulin they need.
The automated artificial pancreas could not only improve the quality of life for people with insulin treated diabetes but also reduce the escalating healthcare cost burden.

In the first phase of the <a href="mailto:AP@home">AP@home</a> project, the currently available AP algorithms were tested with monitoring systems and insulin pumps already on the market, using a “two-port” approach that requires two skin punctures to attach the glucose monitor and the insulin pump. In this stage, the aim was to improve the accuracy of the glucose sensors and the safety and effectiveness of the algorithms that relate insulin delivery to blood glucose levels.

In parallel, innovative AP systems were developed that combine an insulin pump and a CGM system into a single device that uses only one access point through the skin. In the final year of the 4-year project, the performance of the newly created AP system, including remote monitoring facilities, will be compared with standard intensive insulin therapy in daily life in a multinational controlled trial. 

Objective

The objective of AP@home is to build and evaluate an artificial pancreas (AP) with automated closed loop glycaemic control for insulin treated patients with diabetes. AP systems require algorithms using blood glucose levels obtained via glucose monitoring for controlling subcutaneous insulin administration. First, well established subcutaneous continuous glucose sensors and insulin pumps will be combined to improve and verify the functionality of enhanced closed-loop algorithms. We will advance algorithm quality, improve sensors by bringing their accuracy below the desired 5% error level and add a remote hypoglycaemia alarm. Second, in parallel, two AP systems will be developed by combining an insulin pump and a sensor into a single device, using only one access point through the skin ("single-port"). Thereby the need to puncture the skin twice, once for the glucose sensor and once for the insulin infusion, can be avoided ("two-port"). If proven successful in computer simulations we will evaluate the best selected single-port system under clinical conditions.Deliverables include: description of more precise glucose sensing methods; description of system integration of the two-port and both single-port AP systems; validation of prototypes in the clinic and at home. In a multinational controlled trial AP performance will be compared with standard intensive insulin therapy in daily life.Impact of the project includes strengthened competitiveness of European industry across a complete value chain involving large, mid-sized and small companies, enabling Europe to lead progress in AP systems. Also, the project will put European research and clinical organizations in leading positions with an increased number of high-skilled jobs in the medical device industry. Finally, diabetes care will be simplified, quality of life of patients with diabetes will be improved and diabetes related complications and health costs will diminish in the long run.

Related information

Coordinator

Profil Institut fur Stoffwechselforschung GmbH
Germany

EU contribution: EUR 1 690 300


Hellersbergstrasse 9
41460 Neuss
Germany
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative contact: Lutz Heinemann
Tel.: +49 2131 4018 402
Fax: +49 2131 4018 564

Contact the organisation

Participants

4A ENGINEERING GMBH
Austria

EU contribution: EUR 375 470


INDUSTRIEPARK 1
8772 TRABOCH
Austria
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative contact: Reinhard Hafellner
Tel.: +43 3842 45106
Fax: +43 3842 45106 780

Contact the organisation

Medical University of Graz
Austria

EU contribution: EUR 1 497 020


Auenbruggerplatz
8036 Graz
Austria
Activity type: Higher or Secondary Education Establishments
Administrative contact: Martin Ellmerer
Tel.: +43 699 19214356
Fax: +43 316 385 72839

Contact the organisation

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland

EU contribution: EUR 667 780


BATIMENT CE 3316 STATION 1
1015 LAUSANNE
Switzerland
Activity type: Higher or Secondary Education Establishments
Administrative contact: Harm-Anton Klok
Tel.: +41 21 693 48 66
Fax: +41 21 693 56 50

Contact the organisation

Sensile Medical AG
Switzerland

EU contribution: EUR 822 398


Fabrikstrasse 10
4614 HAGENDORF
Switzerland
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative contact: Derek Brandt
Tel.: +41 62 2097171
Fax: +41 62 2097101

Contact the organisation

CENTRE HOSPITALIER UNIVERSITAIRE MONTPELLIER
France

EU contribution: EUR 578 356


AVENUE DU DOYEN GASTON GIRAUD 191
34000 MONTPELLIER
France
Activity type: Research Organisations
Administrative contact: Valérie THORIN
Tel.: +33 467 33 96 43
Fax: +33 467 33 08 64

Contact the organisation

UNIVERSITA DEGLI STUDI DI PAVIA
Italy

EU contribution: EUR 493 672


STRADA NUOVA 65
27100 PAVIA
Italy
Activity type: Higher or Secondary Education Establishments
Administrative contact: Sofia Baggini
Tel.: +39 0382 984227
Fax: +39 0382 986906

Contact the organisation

UNIVERSITA DEGLI STUDI DI PADOVA
Italy

EU contribution: EUR 1 225 344


VIA 8 FEBBRAIO 2
35122 PADOVA
Italy
Activity type: Higher or Secondary Education Establishments
Administrative contact: MARIA BERNINI
Tel.: +39 049 8277580
Fax: +39 049 8277771

Contact the organisation

STMICROELECTRONICS SRL
Italy

EU contribution: EUR 474 972


VIA C.OLIVETTI 2
20864 AGRATE BRIANZA
Italy
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative contact: NADIA SERINA
Tel.: +39 039 6036175
Fax: +39 039 6036154

Contact the organisation

Academisch Medisch Centrum bij de Universiteit van Amsterdam
Netherlands

EU contribution: EUR 917 622


MEIBERGDREEF 9
1105AZ AMSTERDAM
Netherlands
Activity type: Higher or Secondary Education Establishments
Administrative contact: Martijn Wiesenekker
Tel.: +31205665912

Contact the organisation

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

EU contribution: EUR 1 044 868


TRINITY LANE THE OLD SCHOOLS
CB2 1TN CAMBRIDGE
United Kingdom
Activity type: Higher or Secondary Education Establishments
Administrative contact: Keith Cann
Tel.: +44 1223 333 543
Fax: +44 1223 332 988

Contact the organisation

Triteq Ltd
United Kingdom

EU contribution: EUR 531 209


STATION ROAD STATION YARD UNIT 1
RG17 0DY HUNGERFORD BERKSHIRE
United Kingdom
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative contact: Steve Lane
Tel.: +44 1488 684554
Fax: +44 1488 685335

Contact the organisation

4a MEDICOM GMBH
Austria

EU contribution: EUR 17 820


Industriepark 1
8772 Traboch
Austria
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative contact: Reinhard Hafellner
Tel.: +43384245106610
Fax: +43384245106780

Contact the organisation

UNIVERSITE MONTPELLIER I.
Participation ended
France

EU contribution: EUR 163 020


Bd Henri IV,5
34060 MONTPELLIER
France
Activity type: Higher or Secondary Education Establishments
Administrative contact: Marie France HYACINTHE
Tel.: +33 467 417 445
Fax: +33 467 417 526

Contact the organisation

UNIVERSITE DE MONTPELLIER
France

EU contribution: EUR 0


163 RUE AUGUSTE BROUSSONNET
34090 MONTPELLIER
France
Activity type: Higher or Secondary Education Establishments
Administrative contact: Valérie THORIN
Tel.: +33 467 33 96 43
Fax: +33 467 33 08 64

Contact the organisation

Follow us on: RSS Facebook Twitter YouTube Managed by the EU Publications Office Top