Community Research and Development Information Service - CORDIS

FP7 APatHome

AP@home

Project reference: 247138
Funded under

Bringing the artificial pancreas home

From 2010-02-01 to 2014-10-31

Project details

Total cost:

EUR 13 639 751

EU contribution:

EUR 10 499 851

Coordinated in:

Germany

Call for proposal:

FP7-ICT-2009-4See other projects for this call

Funding scheme:

CP - Collaborative project (generic)

In order to improve treatment of diabetes patients at home, the main goal of AP@Home is to build and evaluate an artificial pancreas (AP). The AP will allow automated glucose control: It monitors your blood glucose (sugar) levels and a software algorithm calculates how much insulin to deliver at any time via a built-in insulin infusion pump.

Normally, insulin is given either by injections or via continuous infusion pumps. However, blood glucose levels can be greatly affected by many factors such as diet, physical activity, illness and stress so that it is difficult for patients to judge how much insulin they need.
The automated artificial pancreas could not only improve the quality of life for people with insulin treated diabetes but also reduce the escalating healthcare cost burden.

In the first phase of the AP@home project, the currently available AP algorithms were tested with monitoring systems and insulin pumps already on the market, using a “two-port” approach that requires two skin punctures to attach the glucose monitor and the insulin pump. In this stage, the aim was to improve the accuracy of the glucose sensors and the safety and effectiveness of the algorithms that relate insulin delivery to blood glucose levels.

In parallel, innovative AP systems were developed that combine an insulin pump and a CGM system into a single device that uses only one access point through the skin. In the final year of the 4-year project, the performance of the newly created AP system, including remote monitoring facilities, will be compared with standard intensive insulin therapy in daily life in a multinational controlled trial. 

Objective

The objective of AP@home is to build and evaluate an artificial pancreas (AP) with automated closed loop glycaemic control for insulin treated patients with diabetes. AP systems require algorithms using blood glucose levels obtained via glucose monitoring for controlling subcutaneous insulin administration. First, well established subcutaneous continuous glucose sensors and insulin pumps will be combined to improve and verify the functionality of enhanced closed-loop algorithms. We will advance algorithm quality, improve sensors by bringing their accuracy below the desired 5% error level and add a remote hypoglycaemia alarm. Second, in parallel, two AP systems will be developed by combining an insulin pump and a sensor into a single device, using only one access point through the skin ("single-port"). Thereby the need to puncture the skin twice, once for the glucose sensor and once for the insulin infusion, can be avoided ("two-port"). If proven successful in computer simulations we will evaluate the best selected single-port system under clinical conditions.Deliverables include: description of more precise glucose sensing methods; description of system integration of the two-port and both single-port AP systems; validation of prototypes in the clinic and at home. In a multinational controlled trial AP performance will be compared with standard intensive insulin therapy in daily life.Impact of the project includes strengthened competitiveness of European industry across a complete value chain involving large, mid-sized and small companies, enabling Europe to lead progress in AP systems. Also, the project will put European research and clinical organizations in leading positions with an increased number of high-skilled jobs in the medical device industry. Finally, diabetes care will be simplified, quality of life of patients with diabetes will be improved and diabetes related complications and health costs will diminish in the long run.

Related information

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Multimedia

Coordinator

Profil Institut fur Stoffwechselforschung GmbH
Germany

EU contribution: EUR 1 690 300


Hellersbergstrasse 9
41460 Neuss
Germany
Administrative contact: Lutz Heinemann
Tel.: +49 2131 4018 402
Fax: +49 2131 4018 564
E-mail

Participants

MEDIZINISCHE UNIVERSITAT GRAZ
Austria

EU contribution: EUR 1 497 020


AUENBRUGGERPLATZ 2
8036 GRAZ
Austria
Administrative contact: Martin Ellmerer
Tel.: +43 699 19214356
Fax: +43 316 385 72839
E-mail
4A ENGINEERING GMBH
Austria

EU contribution: EUR 375 470


INDUSTRIEPARK 1
8772 TRABOCH
Austria
Administrative contact: Reinhard Hafellner
Tel.: +43 3842 45106
Fax: +43 3842 45106 780
E-mail
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland

EU contribution: EUR 667 780


BATIMENT CE 3316 STATION 1
1015 LAUSANNE
Switzerland
Administrative contact: Harm-Anton Klok
Tel.: +41 21 693 48 66
Fax: +41 21 693 56 50
E-mail
Sensile Medical AG
Switzerland

EU contribution: EUR 822 398


Fabrikstrasse 10
4614 HAGENDORF
Switzerland
Administrative contact: Derek Brandt
Tel.: +41 62 2097171
Fax: +41 62 2097101
E-mail
CENTRE HOSPITALIER UNIVERSITAIRE MONTPELLIER
France

EU contribution: EUR 578 356


AVENUE DU DOYEN GASTON GIRAUD 191
34000 MONTPELLIER
France
Administrative contact: Valérie THORIN
Tel.: +33 467 33 96 43
Fax: +33 467 33 08 64
E-mail
UNIVERSITA DEGLI STUDI DI PAVIA
Italy

EU contribution: EUR 493 672


STRADA NUOVA 65
27100 PAVIA
Italy
Administrative contact: Sofia Baggini
Tel.: +39 0382 984227
Fax: +39 0382 986906
E-mail
UNIVERSITA DEGLI STUDI DI PADOVA
Italy

EU contribution: EUR 1 225 344


VIA 8 FEBBRAIO 1848 2
35122 PADOVA
Italy
Administrative contact: MARIA BERNINI
Tel.: +39 049 8277580
Fax: +39 049 8277771
E-mail
STMICROELECTRONICS SRL
Italy

EU contribution: EUR 474 972


VIA C.OLIVETTI 2
20864 AGRATE BRIANZA
Italy
Administrative contact: NADIA SERINA
Tel.: +39 039 6036175
Fax: +39 039 6036154
E-mail
Academisch Medisch Centrum bij de Universiteit van Amsterdam
Netherlands

EU contribution: EUR 917 622


MEIBERGDREEF 9
1105AZ AMSTERDAM
Netherlands
Administrative contact: Martijn Wiesenekker
Tel.: +31205665912
E-mail
Triteq Ltd
United Kingdom

EU contribution: EUR 531 209


STATION ROAD STATION YARD UNIT 1
RG17 0DY HUNGERFORD BERKSHIRE
United Kingdom
Administrative contact: Steve Lane
Tel.: +44 1488 684554
Fax: +44 1488 685335
E-mail
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

EU contribution: EUR 1 044 868


The Old Schools, Trinity Lane
CB2 1TN CAMBRIDGE
United Kingdom
Administrative contact: Keith Cann
Tel.: +44 1223 333 543
Fax: +44 1223 332 988
E-mail
4a MEDICOM GMBH
Austria

EU contribution: EUR 17 820


Industriepark 1
8772 Traboch
Austria
Administrative contact: Reinhard Hafellner
Tel.: +43384245106610
Fax: +43384245106780
E-mail
UNIVERSITE DE MONTPELLIER
France

EU contribution: EUR 0


163 RUE AUGUSTE BROUSSONNET
34090 MONTPELLIER
France
Administrative contact: Valérie THORIN
Tel.: +33 467 33 96 43
Fax: +33 467 33 08 64
E-mail
UNIVERSITE MONTPELLIER I
Participation ended
France

EU contribution: EUR 163 020


BOULEVARD HENRI IV 5
34967 MONTPELLIER
France
Administrative contact: Marie France HYACINTHE
Tel.: +33 467 417 445
Fax: +33 467 417 526
E-mail
Record Number: 94149 / Last updated on: 2016-09-06