Electrochemiluminescent biosensor for screening of coeliac disease

Project Information

ECLOBIOSENS

Grant agreement ID: 237011

Project closed

Start date 1 June 2010

End date 31 May 2012

Funded under

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Total cost No data

EU contribution € 161 899,59

Coordinated by

UNIVERSITAT ROVIRA I VIRGILI
Spain

Objective

The overall objective of ECLOBIOSENS is to develop a generic technological platform for point-of-care diagnostics capable of simultaneous genomic and proteomic electrochemiluminescent detection. As a model system biosensor arrays for the screening of coeliac disease will be developed based on the simultaneous detection of nucleic acids (HLA typing) and protein molecular markers (auto-antibodies) associated with genetic predisposition and early diagnosis of coeliac disease. The combined detection strategy could be used for general population screening, or just the HLA typing could be used for neonatal screening; or alternatively just the auto-antibody detection could be used for monitoring compliance with the identified diet, or recurrence of the disease due to non-compliance. Additionally false negatives due to coeliacs with IgA deficiency will be avoided by screening for both IgA and IgG auto-antibodies. Together with classical assay formats, novel biomolecule detection schemes based on supramolecular associations will be developed with the aim to fine tune the specificity and sensitivity of the assays. The advantages of the proposed biosensor system include their ease of use, their sensitivity, their inherent selectivity (preventing problems due to interfering substances), their versatility (allowing ‘in-field’ use) and their cost effectiveness.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

• engineering and technology › electrical engineering, electronic engineering, information engineering › electronic engineering › sensors › biosensors
• natural sciences › biological sciences › biochemistry › biomolecules › nucleic acids
• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• medical and health sciences › health sciences › nutrition

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Programme(s)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Topic(s)

• FP7-PEOPLE-IIF-2008 - Marie Curie Action: "International Incoming Fellowships"

Call for proposal

FP7-PEOPLE-IIF-2008
See other projects for this call

Funding Scheme

MC-IIF - International Incoming Fellowships (IIF)

Coordinator

UNIVERSITAT ROVIRA I VIRGILI

• EU contribution: € 161 899,59
• Address: CARRER DE ESCORXADOR ; 43003 Tarragona ; Spain
• Region: Este › Cataluña › Tarragona
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data