Paving the way toward HIV eradication/control

Objetivo

Human Immunodeficiency virus type 1 (HIV-1), the causative agent of AIDS, infects primarily cells of the immune system. The outcome of HIV-1 infection results from complex interactions between viral proteins and host cell factors (ref). In most cases, HIV-1 successfully hijacks cellular pathways and bypasses cellular restriction factors for optimal replication leading to continuous rounds of infection, replication and cell death (ref). Continuous viral replication causes the loss of CD4+T cells and progression to immunodeficiency in infected individuals. However, in certain situations virus replication can be successfully controlled. First, HAART (Highly Active AntiRetroviral Therapy) treatment revealed the existence of a pool of resting memory CD4+ T cells harbouring integrated but silent HIV-1 provirus. Although this situation occurs in a small number of cells, it suggests that intracellular defence mechanisms can be effective against HIV. This long lived viral reservoir is believed to be the major obstacle against HIV-1 eradication by HAART. Second, HIV-infected individuals who are able to control their virus to undetectable levels for many years in absence of any treatment have been identified and referred to as Elite HIV controllers EC . Again, this is a rare situation observed in 0.5% of infected patients. Still, it demonstrates that it is possible to naturally and effectively control HIV replication and disease progression. A common feature of these two situations is that virus replication is controlled at the gene expression level. A major challenge in the HIV field is to understand how these naturally occurring situations where intracellular defence and/or immune response win the battle against HIV. Our project aim at identifying the host factors and define the molecular mechanisms involved in the control of virus replication both in HAART-treated and in EC patients.

Ámbito científico

Régimen de financiación

ERC-AG - ERC Advanced Grant

Institución de acogida

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

Aportación de la UE

€ 2 019 500,00

Dirección

RUE MICHEL ANGE 3
75794 Paris
Francia

Región

Ile-de-France Ile-de-France Paris

Tipo de actividad

Research Organisations

Investigador principal

Monsef Benkirane (Dr.)

Contacto administrativo

Ghislaine Gibello (Ms.)

Enlaces

Contactar con la organización Sitio web

Coste total

Sin datos

Beneficiarios (1)