Objective Metal catalyzed C-H bond functionalization reactions is an area of organic synthesis having an exponential development and a great acceptation in the chemist community because meets the ideals of green chemistry. In this proposal we present a project research based on the development of new strategies of C-H bond activation/cycloaddition that leads to the formation of functionalized heterocycles. Furthermore the methodology is proposed to be applied to the synthesis of piperidine acid analogs, known prenyltransferase inhibitors. The inhibition of prenyltransferases could prevent the proper functioning of the Ras (protein), which is commonly abnormally active in cancer, and it could be key for the development of new therapeutics in the fight against this widespread illness. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicineoncology Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2009-RG - Marie Curie Action: "Reintegration Grants" Call for proposal FP7-PEOPLE-2009-RG See other projects for this call Funding Scheme MC-ERG - European Re-integration Grants (ERG) Coordinator UNIVERSIDAD DE SANTIAGO DE COMPOSTELA EU contribution € 45 000,00 Address COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N 15782 Santiago De Compostela Spain See on map Region Noroeste Galicia A Coruña Activity type Higher or Secondary Education Establishments Administrative Contact Fernando Sedano Arnaez (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data