Improvement of current and development of new vaccines for theileriosis and babesios of small ruminants

Project Information

PIROVAC

Grant agreement ID: 245145

Project closed

Start date 1 April 2010

End date 30 September 2014

Funded under

• Specific Programme "Cooperation": Food, Agriculture and Biotechnology

Total cost € 4 059 031,40

EU contribution € 2 999 994,00

Coordinated by

FORSCHUNGSZENTRUM BORSTEL LEIBNIZ LUNGENZENTRUM
Germany

Objective

The proposal deals with the establishment of control measures for two major tick-borne diseases of small ruminants: theileriosis caused by Theileria lestoquardi and T. uilenbergi and babesiosis caused by Babesia ovis. The research programme aims at improving existing and producing new attenuated vaccines, designing subunit vaccines and capability building. To achieve these goals the proposal will assess parasite diversity and identify molecules associated with attenuation of parasite virulence to be included in the development of safe and efficacious live vaccines. For the design of a subunit vaccine parasite molecules will be identified and characterized involved in i) invasion of host cells ii) activation of CD4+ T cells and NK cells for the production of cytokines capable of activating macrophages for killing of the parasites and iii) activation of cytotoxic T-lymphocytes involved in killing of T. lestoquardi-infected leucocytes. For improvement of attenuated vaccines, a combination of vaccine with subunit vaccine will be examined for synergistic effects and reducing the need of a cold chain by improving storage conditions/ shelf life of vaccine will be aimed for. Groups working on Plasmodium are involved with the goal to benefit from the scientific and technological knowledge in this field and to translate it into tools and reagents for small ruminant piroplasms. Industrial expertise regarding vaccine development and delivery systems will be incorporated in the whole project. The impact of the vaccine to be produced against these emerging tick-borne diseases will be enormous, as they pose a great threat to livestock production, and a contribution will be made that will meet critical Millennium development goals: food security, food safety, poverty alleviation, animal welfare and environmental sustainability.

Fields of science

• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › vaccines
• engineering and technology › other engineering and technologies › food technology › food safety
• medical and health sciences › health sciences › nutrition
• agricultural sciences › animal and dairy science › domestic animals › animal husbandry

Programme(s)

• FP7-KBBE - Specific Programme "Cooperation": Food, Agriculture and Biotechnology

Topic(s)

• KBBE-2009-1-3-04 - Tick borne diseases. Improvement of current vaccine and development of new vaccines for theileriosis and babesiosis through exploitation of genomic data – SICA (China and Central Asia)

Call for proposal

FP7-KBBE-2009-3
See other projects for this call

Funding Scheme

CP-FP-SICA - Small/medium-scale focused research project for specific cooperation actions dedicated to international cooperation partner countries(SICA)

Coordinator

FORSCHUNGSZENTRUM BORSTEL LEIBNIZ LUNGENZENTRUM

• EU contribution: € 835 890,00
• Address: PARKALLEE 1-40 ; 23845 Borstel ; Germany
• Region: Schleswig-Holstein › Schleswig-Holstein › Segeberg
• Activity type: Research Organisations
• Administrative Contact: Jabbar Ahmed (Prof.)
• Total cost: No data

Participants (14)

UNIVERSITY OF GLASGOW

United Kingdom

• EU contribution: € 254 500,00
• Address: UNIVERSITY AVENUE ; G12 8QQ Glasgow
• Region: Scotland › West Central Scotland › Glasgow City
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Brian Shiels (Prof.)
• Total cost: No data

LANZHOU VETERINARY RESEARCH INSTITUTE

China

• EU contribution: € 180 000,00
• Address: Xujiaping 11 ; 730046 Lanzhou, Gansu
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Hong Yin (Prof.)
• Total cost: No data

BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN

Germany

• EU contribution: € 180 000,00
• Address: BERNHARD NOCHT STRASSE 74 ; 20359 Hamburg
• Region: Hamburg › Hamburg › Hamburg
• Activity type: Research Organisations
• Administrative Contact: Volker Heussler (Dr.)
• Total cost: No data

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

• EU contribution: € 150 000,00
• Address: RUE DE TOLBIAC 101 ; 75654 Paris
• Region: Ile-de-France › Ile-de-France › Paris
• Activity type: Research Organisations
• Administrative Contact: Annick Bertault (Mrs.)
• Total cost: No data

MINISTRY OF AGRICULTURE AND RURAL DEVELOPMENT

Israel

• EU contribution: € 80 500,00
• Address: . ; 50250 BEIT DAGAN
• Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
• Administrative Contact: Varda Shkap (Dr.)
• Total cost: No data

UNIVERSITAET BERN

Switzerland

• EU contribution: € 150 000,00
• Address: HOCHSCHULSTRASSE 6 ; 3012 Bern
• Region: Schweiz/Suisse/Svizzera › Espace Mittelland › Bern / Berne
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Dirk Albert Eduard Dobbelaere (Prof.)
• Total cost: No data

THE ROYAL VETERINARY COLLEGE

United Kingdom

• EU contribution: € 200 000,00
• Address: ROYAL COLLEGE STREET ; NW1 OTU London
• Region: London › Outer London — West and North West › Barnet
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Turhan Alasya (Mr.)
• Total cost: No data

ADNAN MENDERES UNIVERSITESI

Türkiye

• EU contribution: € 60 000,00
• Address: Adnan Menderes Universitesi Rektorlugu, Merkez Kampus Aytepe Mvkii ; 09010 AYDIN
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Tulin Karagenc (Dr.)
• Total cost: No data

THE UNIVERSITY OF EDINBURGH

United Kingdom

• EU contribution: € 200 000,00
• Address: OLD COLLEGE, SOUTH BRIDGE ; EH8 9YL Edinburgh
• Region: Scotland › Eastern Scotland › Edinburgh
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Angela Noble (Ms.)
• Total cost: No data

PARCO TECNOLOGICO PADANO S.R.L.

Italy

• EU contribution: € 170 000,00
• Address: Via Einstein - Localita Cascina Codazza ; 26900 LODI
• Region: Nord-Ovest › Lombardia › Lodi
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Gianluca Carenzo (Dr.)
• Total cost: No data

INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICA

Portugal

• EU contribution: € 130 000,00
• Address: AVENIDA DA REPUBLICA QUINTA DO MARQUES ; 2781-901 Oeiras
• Region: Continente › Área Metropolitana de Lisboa › Área Metropolitana de Lisboa
• Activity type: Research Organisations
• Administrative Contact: Nuno Santos (Dr.)
• Total cost: No data

ECOLE NATIONALE VETERINAIRE, AGROALIMENTAIRE ET DE L'ALIMENTATION NANTES ATLANTIQUE

France

• EU contribution: € 130 000,00
• Address: Site de la Chantrerie, Route de Gachet ; 44307 Nantes
• Region: Pays de la Loire › Pays de la Loire › Loire-Atlantique
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Alain Chauvin (Prof.)
• Total cost: No data

INSTITUTO NACIONAL DE TECNOLOGIA AGROPECUARIA

Argentina

• EU contribution: € 100 000,00
• Address: RIVADAVIA 1439 ; C1033AAE BUENOS AIRES
• Activity type: Research Organisations
• Administrative Contact: Ezequiel Duffard (Mr.)
• Total cost: No data

INTERVET INTERNATIONAL BV

Participation ended

Netherlands

• EU contribution: € 179 104,00
• Address: WIM DE KORVERSTRAAT 35 ; 5831 AN Boxmeer
• Region: Zuid-Nederland › Noord-Brabant › Noordoost-Noord-Brabant
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Theo Schetters (Prof.)
• Total cost: No data