Objective
Cells contain in-built checkpoint mechanisms to halt division when cells are somehow compromised in their ability to replicate properly, allowing time to repair or adjust the inflicted machinery. If the damage signal persists, cells eventually undergo irreversible cellular faiths, including cellular senescence or apoptosis. Of interest to cancer researchers, apoptosis and senescence upon prolonged oncogene activation or loss of tumor suppression is an emerging paradigm, and is even detected in early stage human tumors. I reasoned that a senescence screen should reveal novel cancer genes, and undertook a kinome siRNA screen employing a cell based morphology screen in diploid, untransformed epithelial cells. One of the candidate tumor suppressors thus identified was the EPHA3 receptor tyrosine kinase gene, which is found to be frequently mutated in human lung and colorectal cancers in several cancer genome sequencing efforts. However the details of how receptor mutation contributes to tumour formation remain unclear. We aim to further explore these research angles through studying molecular networks around and cell system responses to the manipulation of EphA3 receptor signalling. Considering the role of Eph receptors in cell shape and migration, it will be essential to study its putative tumour suppressive functions in a system resembling in vivo architecture. The integration of molecular, cell biological and epithelial cellular system approaches with genomic profiling will add to our understanding of this poorly studied cancer pathway. Furthermore, an understanding of checkpoint responses to cancer mutations, including EphA3 pathway alterations, may enable us to shift responses towards apoptosis or prevent checkpoint escape and reveal cancer prevention strategies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine oncology colorectal cancer
- natural sciences biological sciences genetics mutation
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-RG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
00014 HELSINGIN YLIOPISTO
Finland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.