Objective
The design and fabrication of biocompatible carrier systems for RNA based medicine and therapeutic antibodies equipped with multiple functions suitable for controlled and targeted delivery is the main scope of this proposal. General strategies for the encapsulation and release of RNA and proteins will be developed on the basis of the Layer by Layer technique (LBL) employing core materials tailored to the physico-chemical properties of the respective medications. Alternatively, RNA and antibodies can be also assembled between polyelectrolyte layers. The multilayers will progressive degrade in extracellular media or after being uptake in cells. The progressive degradation of the multilayer will provide a sustainable delivery of the therapeutic agent. The LBL provides also the means to modify the surface of the carrier to increase circulation or to increase specific uptake, according to the intended therapeutic action. To fulfil this aim biocompatible lipid layers will be engineered onto the surface of the carriers. This lipid coat is furthermore the matrix for the incorporation of targeting functions. The encapsulation of therapeutic antibodies, besides its very general importance, specifically addresses ocular applications, to meet urgent delivery problems. The design of a RNA carriers intended for silencing specific genes addresses a rather challenging problem of delivery. Its solution may help to pave the way for the application of the powerful RNA tools as therapeutic agents. The processing and distribution, in vitro and in vivo, of these carriers will be intensively studied. A comprehensive knowledge of how these processes take place will be paramount for the improvement of the coatings and to enhance their performance. Cyitotoxicity of carriers will also be studied.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences biochemistry biomolecules lipids
- engineering and technology materials engineering coating and films
- natural sciences biological sciences genetics RNA
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IAPP
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-IAPP - Industry-Academia Partnerships and Pathways (IAPP)
Coordinator
20009 San Sebastian
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.