Objective
B cells are responsible for the humoral arm of the immune response and most successful
vaccines in humans are antibody-based. Depending on the pathogen, specific B cell subsets are
mobilized and a variety of innate, intermediate or adaptive responses are produced. In some
cases these responses generate memory in anticipation of a re-encounter with the same pathogen.
B cells can also present antigens to T cells, and enhance or suppress immune responses,
depending in which T cell context they are primed.
The present project aims to describe new innate-like and memory B cell subsets and to
unravel the molecular switch allowing the differentiation and the long-term maintenance
into the memory program. This will be done by combining approaches in both humans and
mice, in order to reveal the analogies and the differences between these two immune
systems.
Our main specific aims are 1) to establish a reporter cell line that, by complementation with a
cDNA library from human centrocytes and memory B cells, should allow the identification of a
master gene able to trigger the memory program 2) to compare various antigenic and
endogenous stimuli in terms of formation of various innate-like and memory subsets, using a
mouse model that, by marking irreversibly B cells during an immune response, has allowed us to
reveal new layers of B-cell memory 3) to study the endogenous and exogenous signals that
support the development of marginal zone B cells in humans 4) to unravel the genes that govern
long-term B cell memory, by isolating anti-vaccinia virus long-lived human memory B cells. The
general ambition is to provide new insights into the complexity of the B cell compartment that
should allow the improvement of B-cell targeted vaccination strategies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences microbiology virology
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2009-AdG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
75654 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.