Obiettivo In this project we aim to develop a series of metal-containing molecules with the ability to interact with specific DNA sequences. More specifically, we will target what is called quadruplex DNA. It has been recently identified that there are approximately 350,000 sequences in the human genome that can potentially form quadruplex DNA structures. More interestingly, some of these regions have already been identified as potential targets for the development of cancer drugs. Therefore, we will aim to develop metal complexes that can selectively interact with these specific quadruplex DNA structures. The project will involve the design (aided by computational methods), development and characterisation of the new molecules. The DNA binding properties of these molecules will be evaluated using a range of techniques (e.g. FRET, FID, SPR and CD). This will allow us to identify lead molecules (those that interact more strongly and selectively with specific quadruplex DNA structures) so that their biological activity can be evaluated. Campo scientifico natural sciencesbiological sciencesgeneticsDNAnatural sciencescomputer and information sciencescomputational sciencemedical and health sciencesclinical medicineoncologynatural sciencesbiological sciencesgeneticsgenomes Programma(i) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) FP7-PEOPLE-2009-IEF - Marie Curie Action: "Intra-European Fellowships for Career Development" Invito a presentare proposte FP7-PEOPLE-2009-IEF Vedi altri progetti per questo bando Meccanismo di finanziamento MC-IEF - Intra-European Fellowships (IEF) Coordinatore IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Contributo UE € 172 240,80 Indirizzo SOUTH KENSINGTON CAMPUS EXHIBITION ROAD SW7 2AZ LONDON Regno Unito Mostra sulla mappa Regione London Inner London — West Westminster Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Brooke Alasya (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato
