Objective
Cell survival depends on the integration of numerous signals provided by the extracellular environment. Activation of signal transduction by transmembrane receptors is assumed to occur following interaction with a specific ligand. However, some receptors, called dependence receptors (DRs) have been shown to mediate a signal in the absence of ligand. These receptors share the ability to mediate two opposing signals: in the presence of their cognate ligand, they transduce survival signals, whereas, in the absence of their ligand, they induce apoptosis. This idea was initially proposed for the Deleted in Colorectal Cancer (DCC) receptor, and now, number of such receptors has increased over the past ten years. There are now a dozen DRs described including the netrin-1 receptors DCC and UNC5H1-4, RET, TrkC, neogenin, and Patched. Identifying new dependence receptors is an important challenge since it causes a paradigm shift of a specific signalling pathway and alters our understanding of the developmental and physiological processes involving such receptors. For example, the DRs concept revealed a novel role for DCC in colon cancer, for netrin-1 in breast cancer metastasis and angiogenesis. Despite sharing little structural homology, all DRs contain a Dependence Associated Receptor Transmembrane (DART) motif, induce apoptosis in the absence of ligand and are cleaved by caspases to release a pro-apoptotic fragment. Preliminary data shows that Notch3 shares these characteristics. Notch3 is a member of the family of Notch receptors which regulates various stages in development and cancer as the receptors control cellular differentiation, proliferation and death. Notch3 has never been studied as a dependence receptor and the aim of this application is thus to further characterise Notch3 dependence signalling. We will study the mechanisms of Notch3-induced cell death and its relevance in physiological models, the involution of the mammary gland and lung cancers.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine oncology lung cancer
- medical and health sciences clinical medicine oncology breast cancer
- medical and health sciences clinical medicine oncology colorectal cancer
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IEF
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
69373 LYON
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.