Objective Overall objective and Specific Aims. The overall objective of this proposal is to elucidate the pathogenesis ofHBV infection with the ultimate hope that this knowledge will lead to the development of new therapeuticstrategies to terminate persistent infection and its attendant costs and complications. Our approach is to dissectpoorly understood cellular and molecular pathways responsible for both liver disease and viral clearance takingadvantage of technological advances in the field of live imaging and unique mouse models of HBV infection.Three specific aims will be pursued:1. Visualize and characterize where and how naïve and effector CTL of different specificities adhere tovessels and recognize/kill HBV-expressing hepatocytes within the “normal”, fibrotic/cirrhotic orcancerous liver.2. Characterize the role of platelets in HBV pathogenesis.3. Characterize the role of Kupffer cells in HBV pathogenesis. Fields of science natural sciencesbiological sciencesmicrobiologyvirologymedical and health scienceshealth sciencesinfectious diseasesDNA viruseshepatitis Bnatural sciencesphysical sciencesopticsmicroscopymedical and health sciencesclinical medicinehepatology Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) ERC-AG-LS6 - ERC Advanced Grant - Immunity and infection Call for proposal ERC-2009-AdG See other projects for this call Funding Scheme ERC-AG - ERC Advanced Grant Host institution OSPEDALE SAN RAFFAELE SRL EU contribution € 1 298 620,83 Address VIA OLGETTINA 60 20132 Milano Italy See on map Region Nord-Ovest Lombardia Milano Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Principal investigator Luca Guidotti (Prof.) Administrative Contact Maria Rosa Pedrazzi (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Beneficiaries (2) Sort alphabetically Sort by EU Contribution Expand all Collapse all OSPEDALE SAN RAFFAELE SRL Italy EU contribution € 1 298 620,83 Address VIA OLGETTINA 60 20132 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Principal investigator Luca Guidotti (Prof.) Administrative Contact Maria Rosa Pedrazzi (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR Italy EU contribution € 747 579,17 Address Via Olgettina 60 20132 MILANO See on map Region Nord-Ovest Lombardia Milano Activity type Research Organisations Administrative Contact Mario Valsecchi (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data