Objective
Overall objective and Specific Aims. The overall objective of this proposal is to elucidate the pathogenesis of
HBV infection with the ultimate hope that this knowledge will lead to the development of new therapeutic
strategies to terminate persistent infection and its attendant costs and complications. Our approach is to dissect
poorly understood cellular and molecular pathways responsible for both liver disease and viral clearance taking
advantage of technological advances in the field of live imaging and unique mouse models of HBV infection.
Three specific aims will be pursued:
1. Visualize and characterize where and how naïve and effector CTL of different specificities adhere to
vessels and recognize/kill HBV-expressing hepatocytes within the “normal”, fibrotic/cirrhotic or
cancerous liver.
2. Characterize the role of platelets in HBV pathogenesis.
3. Characterize the role of Kupffer cells in HBV pathogenesis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- medical and health sciences health sciences infectious diseases DNA viruses hepatitis B
- natural sciences physical sciences optics microscopy
- medical and health sciences clinical medicine hepatology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2009-AdG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
20132 Milano
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.