Objective
Plant-associated organisms secrete molecules to attenuate plant defence signalling and enable colonization of plant tissue. In contrast to bacterial plant pathogens, only a few oomycete effectors have been characterized. Many oomycete effectors carry a signal peptide and RxLR motif, and act inside host cells to suppress immunity. However, the mechanisms by which these effectors act remain to be elucidated. Jones’ laboratory study candidate effector genes mined from the genome sequence of Arabidopsis downy mildew (Hyaloperonospora arabidopsidis -Hpa) in high-throughput screens and discovered RxLR effectors which enhance/decrease virulence. The present project proposes to analyse in planta, the modes of action of ten promising RxLR effectors from Hpa that confer enhanced/decreased virulence. From these ten promising Hpa candidate effectors, I aim to select as soon as possible the three best candidates to perform in planta functional analysis. In this framework, the main objectives are the subcellular localisation of Hpa effectors in the host cell and the identification of Hpa effector plant targets. The characterization of oomycete effectors that enter the plant cell, their functions and protein-uptake mechanisms will be a fascinating area for understanding the basis of plant pathogenesis and will shed light on fundamental cellular mechanisms in plants, thus enhancing our understanding of plant signalling, metabolism, and cell biology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules
- natural sciences biological sciences cell biology
- natural sciences mathematics pure mathematics mathematical analysis functional analysis
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
NR47UH Norwich
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.