Obiettivo The target of this proposal is ageing and its association with reproduction, immunity and behaviour. This is an area of biology that has intrigued every generation since Aristotle (c. 300 BC). We assess how free radicals (reactive oxygen species), so often identified as factors of ageing and immune disorders, exert selection on living organisms and whether resistance (and defence) towards free radicals may drive evolution of ageing in the wild. In particular, we study (i) how free radicals, the defence systems associated with them and the reproductive and the immune system interact to shape life history trade-offs, (ii) how free radicals impact on survival in the wild and, (iii) how epigenetic factors such as maternal hormones contribute to the formation of behavioural phenotypes (personalities) with different free radical profiles. This project integrates field studies and laboratory experiments using two uniquely suited model species (the Australian Painted dragon lizard and the zebra finch) and combines them with state-of-the-art molecular techniques to investigate variation in free radical production and defences. In spite of excellent work in the laboratory, this is one of the first attempts to study free radicals in the 'real world' and will extend Europe’s excellent reputation in evolutionary biology. Campo scientifico humanitieshistory and archaeologyhistorynatural sciencesbiological sciencesevolutionary biologymedical and health sciencesbasic medicineimmunology Programma(i) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) FP7-PEOPLE-2009-IOF - Marie Curie Action: "International Outgoing Fellowships for Career Development" Invito a presentare proposte FP7-PEOPLE-2009-IOF Vedi altri progetti per questo bando Meccanismo di finanziamento MC-IOF - International Outgoing Fellowships (IOF) Coordinatore MAX IV Laboratory, Lund University Contributo UE € 275 525,90 Indirizzo Paradisgatan 5c 22100 LUND Svezia Mostra sulla mappa Regione Södra Sverige Sydsverige Skåne län Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Dennis Hasselquist (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato