Objective
Association between neural representations of stimuli is believed to be an elementary mechanism for learning. However, the ability to prevent inappropriate associations by separating stimuli into coherent subgroups is no less important. Environment exploration triggers immediate-early gene (IEG) expression in environment-specific hippocampal ensembles, suggesting that distinct contexts are represented by distinct neural ensembles. Fluorescence in situ hybridization (FISH) to two IEGs, Arc and Homer1a is used to map neural activity during two different time epochs. This project will use the Arc/Homer1a FISH imaging to test if discrimination training enhances separation between neural ensembles. Contextual fear discrimination task compares the amount of freezing in a context in which fear conditioning had occurred to freezing in a lure context. Pre-exposure to the conditioning context enhances discrimination of similar contexts. Does it also enhance the ensemble separation? Navigation defined by stable distal cues on a continuously rotating arena requires discrimination of environmental stimuli into two coherent subsets. Does navigation training on the rotating arena enhance separation between neural ensembles representing room and arena stimuli? A hallmark cognitive deficit in schizophrenia is difficulty to process and use contextual information. Animal model of schizophrenia by systemic administration of a non-competitive NMDA receptor antagonist dizocilpine maleate also shows deficit in navigation on the rotating arena. Arc/Homer1a FISH will be used to test if ensemble separation is impaired in the schizophrenia model on the background of the discrimination tasks. The major objectives of this proposal are 1) to test if neural ensemble separation may be the basis for behavioral discrimination; 2) to test if neural ensemble separation is impaired in a model of schizophrenia; 3) to introduce the Arc/Homer1a FISH imaging of neural activity at two time points.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- social sciences sociology social issues social inequalities
- medical and health sciences clinical medicine psychiatry schizophrenia
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-RG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
142 20 Praha 4
Czechia
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.