Obiettivo Heart failure is a major cause of mortality and morbidity, and often the consequence of pathological cardiac hypertrophy. Upon entering hypertrophy, cells undergo a vast transcriptional remodelling, with thousands of genes being either up- or down-regulated. In the last years it became evident that epigenetic modifications are an important determinant of transcriptional changes, and several lines of evidence demonstrate that epigenome modulating enzymes are implicated in cardiac hypertrophy. In the present project we propose to study transcriptional repression by DNA and histone methylation. We will map these modifications and use this map to identify and study the methyl transferases, transcription factors and pathways that underlie these modifications using a systems-biology approach. The insight that is to be anticipated from this study will not only enhance our understanding of transcription regulation in hypertrophy, it can also provide a novel entry point for strategies to treat this disorder. Campo scientifico social sciencessociologydemographymortalitynatural sciencesbiological sciencesgeneticsDNAmedical and health sciencesclinical medicinecardiologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymesnatural sciencesbiological sciencesgeneticsepigenetics Programma(i) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) FP7-PEOPLE-2009-IEF - Marie Curie Action: "Intra-European Fellowships for Career Development" Invito a presentare proposte FP7-PEOPLE-2009-IEF Vedi altri progetti per questo bando Meccanismo di finanziamento MC-IEF - Intra-European Fellowships (IEF) Coordinatore THE BABRAHAM INSTITUTE Contributo UE € 171 740,80 Indirizzo Babraham Hall CB22 3AT Cambridge Regno Unito Mostra sulla mappa Regione East of England East Anglia Cambridgeshire CC Tipo di attività Research Organisations Contatto amministrativo Fang Gao (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato
