Cel Large non-coding RNAs and microRNAs are important regulators of gene expression that may control both physiological and pathological processes such as neurodegenerative disorders. Given the complexity of neurodegenerative disorders, studying the role of non-coding RNAs would be necessary to understand the molecular mechanisms underlying ageing related neurodegeneration. Of particular interest, microRNAs (miRNAs) seem to participate directly in the regulation of Alzheimer’s Disease (AD) and Parkinson’s Disease (PD) related genes. In this regard, microRNA research would be promising for the understanding of the very prevalent and poorly understood sporadic forms of AD and possibly PD. To address the role of specific microRNAs in biological models, the project will consist in determining whether down-regulation of specific microRNAs in zebrafish and mouse models recapitulate neurodegeneration. The identification of mRNA targets of such microRNAs will provide insight into the cellular pathways that are disturbed after microRNA knock-down. To complement the study on microRNAs, another objective of the project will be to determine whether large non-coding RNAs are dysregulated in neurodegenerative diseases similar to what is observed for microRNAs. The study of non-coding RNAs will provide a novel layer of complexity in neuronal cell biology and be exciting tools to probe and discover molecular mechanisms underlying neurodegeneration. Dziedzina nauki natural sciencesbiological sciencesneurobiologymedical and health sciencesbasic medicineneurologydementiaalzheimernatural sciencesbiological sciencescell biologynatural sciencesbiological sciencesgeneticsRNAmedical and health sciencesbasic medicineneurologyparkinson Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) FP7-PEOPLE-2009-IIF - Marie Curie Action: "International Incoming Fellowships" Zaproszenie do składania wniosków FP7-PEOPLE-2009-IIF Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-IIF - International Incoming Fellowships (IIF) Koordynator VIB VZW Wkład UE € 214 800,00 Adres SUZANNE TASSIERSTRAAT 1 9052 ZWIJNAARDE - GENT Belgia Zobacz na mapie Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Rodzaj działalności Research Organisations Kontakt administracyjny Rik Audenaert (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
