The biological clock and cancer

Project Information

CANCERTIME

Grant agreement ID: 255230

Project closed

Start date 1 February 2011

End date 31 January 2014

Funded under

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Total cost € 250 773,70

EU contribution € 250 773,70

Coordinated by

KAROLINSKA INSTITUTET
Sweden

Objective

The circadian clock generates and regulates many daily physiological and behavioural rhythms and thereby also influences the health of the organism. This knowledge has been useful for treating various diseases including cancer. In cancer therapy, survival rate and secondary effects can be improved by applying the treatment at the right time of day. However, the mechanisms by which the clock influences cancer development and treatment effects are not well understood. In the outgoing phase of the grant I will study how the functionality of circadian clocks in tumor and healthy tissue influences tumor development and response to treatment in Dr. Antoch’s research group at the Roswell Cancer Institute in Buffalo, USA. I will use a unique mouse model which allows visualization of the clock in real time by using bioluminescence imaging technology. I will study in vivo how changes in the clock relate to tumor development. I will further experimentally regulate the expression of clock genes to investigate how disrupting the clock affects tumor development both in vitro, using cell lines, and in vivo, by inoculating healthy mice with manipulated tumors. In a final step, in the return phase of the grant I will work together with Dr. Selivanova at the Karolinska Institutet in Stockholm, Sweden where I will test how potential anticancer drugs interact with the circadian clock and the apoptosis pathway.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

• medical and health sciences › clinical medicine › oncology

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Programme(s)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Topic(s)

• FP7-PEOPLE-2009-IOF - Marie Curie Action: "International Outgoing Fellowships for Career Development"

Call for proposal

FP7-PEOPLE-2009-IOF
See other projects for this call

Funding Scheme

MC-IOF - International Outgoing Fellowships (IOF)

Coordinator

KAROLINSKA INSTITUTET

• EU contribution: € 250 773,70
• Address: Nobels Vag 5 ; 17177 Stockholm ; Sweden
• Region: Östra Sverige › Stockholm › Stockholms län
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data