Objective
Pandemic influenza, such as the 2009 H1N1 influenza virus strains that recently emerged in Mexico and in the US, can have serious effects on human health. Development of vaccines that are able to elicit more potent and protective immune responses as well as reducing the impact of future pandemic outbreaks is critical. Successful development of such vaccines is dependent on animal models to test vaccine efficacy and safety. Animal modeling of infectious disease also allows for transcription mapping of the cellular and molecular mechanisms by which these viruses infect as well as how the vaccines against them provide protection. We will use the ferret influenza model to build a comprehensive map the genes signatures involved at the different stages of the immune response to influenza virus infection. We will also analyze the transcriptional profiles induced by vaccination using standard inactivated and live attenuated influenza vaccine currently being administered to humans. In addition, we will study the gene expression responses triggered by virus challenge in vaccinated animals. Careful mapping of the gene responses triggered by influenza infection, as well as the mechanisms the virus use to overcome these responses will provide key information for development of vaccines and antiviral drugs against epidemic and pandemic influenza strains.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health epidemiology pandemics
- medical and health sciences health sciences infectious diseases RNA viruses influenza
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antivirals
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
171 77 STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.