Objective Pandemic influenza, such as the 2009 H1N1 influenza virus strains that recently emerged in Mexico and in the US, can have serious effects on human health. Development of vaccines that are able to elicit more potent and protective immune responses as well as reducing the impact of future pandemic outbreaks is critical. Successful development of such vaccines is dependent on animal models to test vaccine efficacy and safety. Animal modeling of infectious disease also allows for transcription mapping of the cellular and molecular mechanisms by which these viruses infect as well as how the vaccines against them provide protection. We will use the ferret influenza model to build a comprehensive map the genes signatures involved at the different stages of the immune response to influenza virus infection. We will also analyze the transcriptional profiles induced by vaccination using standard inactivated and live attenuated influenza vaccine currently being administered to humans. In addition, we will study the gene expression responses triggered by virus challenge in vaccinated animals. Careful mapping of the gene responses triggered by influenza infection, as well as the mechanisms the virus use to overcome these responses will provide key information for development of vaccines and antiviral drugs against epidemic and pandemic influenza strains. Fields of science natural sciencesbiological sciencesmicrobiologyvirologymedical and health scienceshealth sciencespublic healthepidemiologypandemicsmedical and health scienceshealth sciencesinfectious diseasesRNA virusesinfluenzamedical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2009-IIF - Marie Curie Action: "International Incoming Fellowships" Call for proposal FP7-PEOPLE-2009-IIF See other projects for this call Funding Scheme MC-IIF - International Incoming Fellowships (IIF) Coordinator KAROLINSKA INSTITUTET EU contribution € 239 693,20 Address Nobels Vag 5 17177 Stockholm Sweden See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Peter Liljeström (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
