Objective
Clostridium difficile is a Gram-positive, spore-forming anaerobic bacillus that often resides in the gut of mammals and is the causative agent of the illness C. difficile infection (CDI). The hospital environment and patients undergoing antibiotic treatment provide a discrete ecosystem where C. difficile persists and select virulent clones thrive. CDI is the most frequent cause of infectious diarrhea in hospitals worldwide, causing in the last decade outbreaks of increased severity in Europe and North America. The continued rise of CDI worldwide has been accompanied by the rapid emergence and transcontinental spread of at least two highly virulent clones that are commonly referred to as 027 and A-B+. The overall aim of this project is to determine the genetic and phenotypic attributes that might explain the emergence of these hypervirulent 027 strains. To this end we will obtain mutants in genes we suspect to be important for 027 strains virulence. Those mutants will be characterized in detail by genetic and phenotypical studies. This project provides a unique opportunity to study the recent emergence of virulence and will contribute more generally to our understanding of how bacterial pathogens evolve.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences ecology ecosystems
- natural sciences biological sciences zoology mammalogy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
WC1E 7HT LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.