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Genetic and phenotipic characterization of emerging hypervirulent Clostridium difficile: role and regulation of virulence factors

Cel

Clostridium difficile is a Gram-positive, spore-forming anaerobic bacillus that often resides in the gut of mammals and is the causative agent of the illness C. difficile infection (CDI). The hospital environment and patients undergoing antibiotic treatment provide a discrete ecosystem where C. difficile persists and select virulent clones thrive. CDI is the most frequent cause of infectious diarrhea in hospitals worldwide, causing in the last decade outbreaks of increased severity in Europe and North America. The continued rise of CDI worldwide has been accompanied by the rapid emergence and transcontinental spread of at least two highly virulent clones that are commonly referred to as 027 and A-B+. The overall aim of this project is to determine the genetic and phenotypic attributes that might explain the emergence of these hypervirulent 027 strains. To this end we will obtain mutants in genes we suspect to be important for 027 strains virulence. Those mutants will be characterized in detail by genetic and phenotypical studies. This project provides a unique opportunity to study the recent emergence of virulence and will contribute more generally to our understanding of how bacterial pathogens evolve.

Zaproszenie do składania wniosków

FP7-PEOPLE-2009-IEF
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Koordynator

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
Wkład UE
€ 172 740,80
Adres
KEPPEL STREET
WC1E 7HT London
Zjednoczone Królestwo

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Region
London Inner London — West Camden and City of London
Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Jana Sabinovska (Ms.)
Linki
Koszt całkowity
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