Objectif Atherothrombosis still represents the major cause of death in developed countries. All forms of atheroma are characterized by a risk of arterial wall rupture leading to clinical complications. This involves medial and adventitial ruptures in abdominal aortic aneurysm (AAA) and intimal cap rupture in vulnerable atherosclerotic plaques. In both cases the rupture may result in the occlusion of an artery by the formation of a thrombus causing an acute event. Being able to predict who is at risk of an acute cardiovascular event is at present one of the major challenges of cardiovascular medicine. MicroRNAs (miRNAs) are small (typically 22 nt in size) regulatory RNA molecules that function to modulate the activity of specific mRNA targets and play important roles in a wide range of physiologic and pathologic processes. Recent studies have revealed that miRNAs are able to modulate different pathological process involved in atherotrombosis. Our working hypothesis is that the development of atherothrombosis is a chronic process that is associated with miRNA dysregulation, that is, altered miRNA expression profiles may be the cause of many of the abnormalities related to atherotrombosis. The aim of this project is to link miRNA dysregulation to pathophysiology of atherothrombosis, with the aim of characterizing novel biomarkers which could be used in the diagnostic, prognostic and therapeutic setting. Champ scientifique medical and health sciencesclinical medicineangiologyvascular diseases Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2009-IEF - Marie Curie Action: "Intra-European Fellowships for Career Development" Appel à propositions FP7-PEOPLE-2009-IEF Voir d’autres projets de cet appel Régime de financement MC-IEF - Intra-European Fellowships (IEF) Coordinateur CHARITE - UNIVERSITAETSMEDIZIN BERLIN Contribution de l’UE € 162 661,00 Adresse Chariteplatz 1 10117 Berlin Allemagne Voir sur la carte Région Berlin Berlin Berlin Type d’activité Higher or Secondary Education Establishments Contact administratif Eveline Fräßdorf Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
