Objective
Ragweed pollen allergy is a new and steadily growing health problem in Europe. The aim of the proposed Marie Curie Fellowship, NOVARA, is to engineer hypoallergenic Amb a 1, the major allergen of ragweed pollen, for use as new vaccine candidates for allergen-specific immunotherapy (SIT). Since conventional SIT may induce undesired IgE-mediated side-effects, there is a need for well defined proteins with reduced or abolished IgE binding capacity and retained T cell-activating capacity, as substitutes for the highly variable natural allergen extracts. Hypoallergenic variants of Amb a 1 have not yet been fully explored. In particular, it is unclear which structural modifications of hypoallergens could improve their effectiveness for use as active components in allergy therapy with minimised risk of anaphylactic side effects and shorter treatment regimens. Thus, a number of hypoallergenic variants, with different sizes and folding status, will be produced within NOVARA and the most promising candidates will be fully characterized, including the analysis of primary structure, folding, surface exposed hydrophobic portions, aggregation status and stability. Human IgE reactivity, allergenicity and T cell responses will be investigated as indicative of their immunogenicity in humans. The in vivo capacity of the candidate vaccines to induce humoral and cellular responses will be evaluated in a murine model. The opportunity to acquire additional scientific skills in molecular biology and immunology, as well as dealing with intellectual property, ethical and management issues, will allow the Applicant to reach a position of professional maturity. NOVARA has industrial and clinical interests and further strengthens the EU research portfolio in the allergy field.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- medical and health sciences clinical medicine allergology
- medical and health sciences basic medicine immunology immunotherapy
- natural sciences biological sciences molecular biology
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IEF
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
5020 Salzburg
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.