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Novel catalytic function in a TIM-barrel scaffold

Cel

The TIM-barrel fold is the most widely found in nature, making up about 6% of the structures in the Protein Data Bank, and has been found in nature to catalyse reactions from five of the six EC classes. These facts all indicate the extraordinary capacity of the TIM-barrel as a reaction container, and suggest that it may be a versatile starting scaffold into which new catalytic capability can be engineered. In this research programme we will use directed evolution approaches, including state-of-the-art gene shuffling techniques developed in the Hollfelder lab at the University of Cambridge to tengineer novel catalytic function into a TIM-barrel scaffold.

Zaproszenie do składania wniosków

FP7-PEOPLE-2009-IIF
Zobacz inne projekty w ramach tego zaproszenia

Koordynator

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Wkład UE
€ 174 240,80
Adres
TRINITY LANE THE OLD SCHOOLS
CB2 1TN Cambridge
Zjednoczone Królestwo

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Region
East of England East Anglia Cambridgeshire CC
Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Keith Cann (Mr.)
Linki
Koszt całkowity
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