Objetivo I will investigate the hypothesis that antimicrobial peptides in insects deal with persistent infections and/or prevent the evolution of resistant bacterial mutants. This will be achieved by looking at two hitherto unrelated areas within a single conceptual and experimental framework: (a) how to prevent the evolution of bacterial resistance against antimicrobials? (b) Why is it adaptive for insects to exhibit long lasting costly immune responses?This research takes a novel approach to understand the evolution of drug resistance in pathogens, one of the most important applied evolutionary questions of our times. Insects produce potent antimicrobials that are considered as future novel antibiotic drugs and provide insight into a multidrug treatment shaped by natural selection. Elucidating the evolution of integrated immune responses will greatly enhance the understanding of immunity in insects, the most speciose metazoan taxon of great importance to human health (vectors) and nutrition (pollinators).I will use the beetle Tenebrio molitor to examine the temporal dynamics of an antibacterial response using proteomics. I will build on this using two series of experiments manipulating the antimicrobial response in-vivo, using RNAi gene knockdowns, and in in-vitro, using synthesised Tenebrio antimicrobials will be carried out. These experiments will investigate the response of the model pathogen Staphyloccocus aureus to the changes in the beetle s multidrug response. S. aureus resistance to these experimental selection arenas will be studied at the phenotypic and genomic level.The results from this research program will (a) inform antibiotic strategies in medical and veterinary science and (b) will change the way we understand the evolution of (insect) immunity Ámbito científico agricultural sciencesveterinary sciencesmedical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibioticsnatural sciencesbiological scienceszoologyentomologymedical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemultidrug resistance Programa(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) ERC-SG-LS8 - ERC Starting Grant - Evolutionary, population and environmental biology Convocatoria de propuestas ERC-2010-StG_20091118 Consulte otros proyectos de esta convocatoria Régimen de financiación ERC-SG - ERC Starting Grant Institución de acogida FREIE UNIVERSITAET BERLIN Aportación de la UE € 931 014,00 Dirección KAISERSWERTHER STRASSE 16-18 14195 Berlin Alemania Ver en el mapa Región Berlin Berlin Berlin Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Michael Hune (Mr.) Investigador principal Jens Olaf Rolff (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Beneficiarios (2) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo FREIE UNIVERSITAET BERLIN Alemania Aportación de la UE € 931 014,00 Dirección KAISERSWERTHER STRASSE 16-18 14195 Berlin Ver en el mapa Región Berlin Berlin Berlin Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Michael Hune (Mr.) Investigador principal Jens Olaf Rolff (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos THE UNIVERSITY OF SHEFFIELD La participación finalizó Reino Unido Aportación de la UE € 361 488,00 Dirección FIRTH COURT WESTERN BANK S10 2TN Sheffield Ver en el mapa Región Yorkshire and the Humber South Yorkshire Sheffield Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Joanne Watson (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
