Objective
Multicomponent reactions (MCR) have recently attracted a great deal of attention as they are considered as a kind of “holy grail” for organic chemists. Although new examples are constantly flourishing in the literature, there are a limited number of processes that allow multiple components to react together in a single operation. We propose to develop new processes involving two consecutive multicomponent reactions that would open a rapid access to biologically relevant 6-membered ring lactones and lactams. The carbon backbone will be generated using a three-component radical cascade between a xanthate, an olefin and a sulfinyl oxime, followed by the hydrolysis of the resident oxime into an aldehyde, which will be one of the partners in the subsequent multicomponent reaction. 3, 4 and 5CR-radical-, /Aldol, /Mannich and /Petasis reactions will thus be studied that should provide a large variety of lactams and lactones in a diastereocontrolled manner. An application of this strategy to the synthesis of relevant alkaloids is also proposed that should illustrate the power of sequential multicomponent reactions in organic synthesis. This conceptually novel approach should lead to valuable intermediates for organic synthesis, with high bond forming efficiency. The project is based on atom and step economy concepts, two of the most important principles of “green and sustainable chemistry”. Although yet at a fundamental level, this research has potent applications in new technologies, including synthesis automation, which is of high industrial interest. This project is also aimed at training a promising organic chemist from an emerging country, in sustainable chemistry, a fundamental objective in chemical sciences. The researcher that should develop this project has been educated in one of the best chemical institute in India, and possesses an excellent scientific background with seven years experience in total synthesis, having led to remarkable achievements.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences organic chemistry aldehydes
- social sciences sociology industrial relations automation
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
33405 TALENCE
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.