Objective
Cell-substrate interactions have a pronounced effect on cell attachment, growth and proliferation in healthy tissues and disease. The complexity of the in vivo setting has fueled in vitro studies on different aspects of cell behavior in response to different material properties. The proposed research project aims at establishing links between substrate properties and the fundamental process of endocytosis, on which limited knowledge currently exists. The use of mechanically and chemically defined, nano-patterned surfaces to probe the cellular mechanisms of regulation of different internalization pathways will be achieved through use of specialized cargoes, fluorescent labeling and imaging techniques. Strong emphasis will be placed on cancer cells, where both derailed endocytosis and abnormal extracellular matrix contribute to the disease. The combination of the researcher’s strong background on endocytosis of nano structures and the host laboratory’s expertise on surface fabrication and cell-surface interactions guarantee implementation of the project. The anticipated results will have a pronounced impact on our understanding of this fundamental cell process and are likely to be of technological interest in the fields of drug delivery and tissue engineering in the near future.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences medical biotechnology tissue engineering
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
69117 Heidelberg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.