Objective
Coeliac disease, a lifelong disorder, has become one of the most common food intolerances. This is due to an autoimmune reaction trigged by the ingestion of gluten a protein present in wheat, rye, secalins and barley; resulting in chronic inflammation of the mucosa of the small intestine. This inflammation results, in the affected person, in several symptoms as: impaired growth, anemia, weight loss, unhappy behavior and malabsorption. Due to the wide clinical spectrum of Coeliac disease its asymptomatic diagnosis is extremely difficult; currently a biopsy of the small intestine and the evaluation of its conformational changes or lesions is the most reliable and commonly used diagnostic approach. Recently susceptibility to Coeliac disease has been shown to be strongly associated with the region of chromosome 6 that codes for the HLA (Human leukocyte antigen) antigens; DQ2 and DQ8 genotypes have been shown to be associated, in almost 100% of the cases, to this disease. Nano-particles have found large interest in electroanalysis due to their enhancement of mass transport, their catalytic properties and their high effective surface area. Recognition and signal generation are key elements in the performance of genosensors. Their integration in a single element is a very important area of research in genosensor technology. Molecular Beacon, short oligonucleotides chains engineered to perform as recognition element and signal generator, is an extremely attractive tool with respect to this need. The most common format of molecular beacon is the fluorescent but more recently electrochemical molecular beacon are gaining ground in the In this work an electrochemical DNA-chip, based on the combination of nano-particles and electrochemical molecular beacon will be developed and characterized and its application to high resolution HLA typing for Coeliac disease predisposition diagnosis will be investigated.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences chemical sciences catalysis
- natural sciences biological sciences genetics chromosomes
- agricultural sciences agriculture, forestry, and fisheries agriculture grains and oilseeds cereals
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-RG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
43003 TARRAGONA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.