Catalytic Enantioselective Dearomatisation : A New Strategy for the Synthesis of Complex Bioactive Natural Products

Projektinformationen

CED

ID Finanzhilfevereinbarung: 253231

Abgeschlossenes Projekt

Startdatum 1 März 2010

Enddatum 30 Juni 2010

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 171 740,80

EU-Beitrag € 171 740,80

Koordiniert durch

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

Ziel

This proposal outlines a blueprint towards the development of a new catalytic strategy for chemical synthesis, wherein catalytic cascade processes are designed around the transformation of a common functional motif to a diversity of enantiopure natural product architectures, in a single step. The hypothesis behind the chemo-catalytic synthesis strategy involves the development of a catalytic enantioselective dearomatization (CED) process that directly converts flat aromatic molecules into complex asymmetric structures. The transformation involves a tandem process, comprising oxidative dearomatization and organocatalytic desymmetrization, generating highly functionalized, non-racemic architectures. The natural product targets structures of alkaloids, polyketide, steroid and terpene biosynthetic origin, and complex non-natural frameworks that may have interesting properties, as the basis for novel small-molecule libraries with untapped biological properties. The programme of research will focus on the exploitation and the development of the cascade ‘zipper-reaction’ concept, CED, wherein simple, linear molecules can be directly converted to complex enantiopure architectures that closely resemble the structures of bioactive natural products. The proposal will have four parts over the two-year period of the proposed Fellowship : the method development for the CED cascade process, the total synthesis of morphine and the development of novel scaffolds for drug discovery. The research outlined in this proposal is a representative part of a 'grand challenge' programme to provide a chemo-catalysis blueprint for synthesis that is inspired by the efficacy of biosynthesis.

Wissenschaftliches Gebiet

• medical and health sciences › basic medicine › pharmacology and pharmacy › drug discovery

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-2009-IEF - Marie Curie Action: "Intra-European Fellowships for Career Development"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2009-IEF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IEF - Intra-European Fellowships (IEF)

Koordinator

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

Kontakt Verwaltung

Keith Cann (Mr.)

• EU-Beitrag: € 171 740,80
• Adresse: TRINITY LANE THE OLD SCHOOLS ; CB2 1TN Cambridge ; Vereinigtes Königreich
• Region: East of England › East Anglia › Cambridgeshire CC
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten