Cel Recently, it has been discovered that the thyroid gland has increased ability to withstand oxidative stress compared to other organs. This important feature allows the gland to maintain its homeostasis in the face of increased burden of free radicals produced during iodine metabolism for thyroid hormone synthesis. Iodine deficiency and goiter are associated with increased oxidative stress in the thyroid. While some antioxidant enzymes are known to be upregulated in the thyroid under such conditions, the broader regulatory mechanisms of oxidative stress resistance remain unknown. The proposed research aims to investigate the role of the major antioxidant response system orchestrated by the transcription factor Nrf2 in thyroid gland homeostasis and thyroid cancer. Specifically, it will examine whether Nrf2 regulates the thyroid’s antioxidant defenses; whether Nrf2 activity in the thyroid is altered during iodine deficiency and goitrogenesis; and whether constitutive Nrf2 activation by somatic mutations is associated with thyroid cancer. These investigations will utilize mouse knockouts of Nrf2 and wild-type animals, primary thyroid cell cultures derived from these mice, and archived thyroid cancer samples from human subjects. This work has implications for the management of iodine deficiency and the prevention of thyroid carcinogenesis. This interdisciplinary research project will be executed by Dr. Gerasimos Sykiotis, a translational investigator who has prior research experience in thyroid gland pathophysiology and has acquired state-of-the-art expertise with the Nrf2 antioxidant response system in the country of origin (USA). The University of Patras Medical Center is a highly qualified host organization as it has in place both the nrf2-/- animals and the human thyroid cancer samples. Lasting professional integration, international collaborations with the USA and European countries, and advanced European competitiveness are features of this proposal. Dziedzina nauki medical and health sciencesbasic medicinephysiologypathophysiologymedical and health sciencesclinical medicineoncologynatural scienceschemical sciencesinorganic chemistryhalogensmedical and health sciencesbasic medicinephysiologyhomeostasisnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) FP7-PEOPLE-2009-RG - Marie Curie Action: "Reintegration Grants" Zaproszenie do składania wniosków FP7-PEOPLE-2010-RG Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-IRG - International Re-integration Grants (IRG) Koordynator PANEPISTIMIO PATRON Wkład UE € 100 000,00 Adres UNIVERSITY CAMPUS RIO PATRAS 265 04 Rio Patras Grecja Zobacz na mapie Region Κεντρική Ελλάδα Δυτική Ελλάδα Αχαΐα Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Ioannis Habeos (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
