Objetivo Peptide-lipid interactions are critical in several biomedical matters that seem uncorrelated at a first glance. MEMPEPACROSS deals with some of these: 1) Lipid membrane-interactions are the key for the understanding of dengue virus assembly and can constitute a target for its inhibition. Viral hemorrhagic fever caused by dengue virus is a serious threat to Europe, as its vector is already present in several European Countries and the virus can easily be introduced. 2) Gene-encoded antimicrobial peptides (AMPs) are innate defenses to prevent colonization and infection by microbial pathogens. Most these peptides strongly interact with lipid membranes. Their antimicrobial efficacy and the difficulty of the target organism to develop resistance make AMPs promising candidates for new generations of drugs to fight highly threatening antibiotic-resistant strains of pathogens. 3) Peptide-membrane interactions are also relevant for neurodegenerative diseases, such as Alzheimer disease. The identification of the conditions necessary for the triggering of the disease-inducing protein aggregation and the search for strategies to inhibit these processes are the key-aspects to be addressed. The societal impacts of the scientific matters to be addressed are golden opportunities to improve public awareness of Science. The project includes a strong component of Science communication and management. The expertises of two European institutions – Institute of Molecular Medicine (Lisbon, Portugal) and Pompeu Fabra University (Barcelona, Spain) – and of three Brazilian institutions – the Federal Universities of Rio de Janeiro and Ceará, and the Oswaldo Cruz Foundation – will come together with common goals and a concern for the: 1) improvement of the scientific state-of-the-art, 2) effective societal impact of the achievements of the project, and 3) dissemination of the project outputs among both technical and non-technical audiences. Ámbito científico natural sciencesbiological sciencesneurobiologymedical and health scienceshealth sciencesinfectious diseasesRNA virusesmedical and health sciencesbasic medicineneurologydementiaalzheimernatural sciencesbiological sciencesmicrobiologyvirologynatural sciencesbiological sciencesbiochemistrybiomoleculeslipids Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) FP7-PEOPLE-2009-IRSES - Marie Curie Action "International Research Staff Exchange Scheme" Convocatoria de propuestas FP7-PEOPLE-2009-IRSES Consulte otros proyectos de esta convocatoria Régimen de financiación MC-IRSES - International research staff exchange scheme (IRSES) Coordinador INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES Aportación de la UE € 118 800,00 Dirección AVENIDA PROF EGAS MONIZ 1649 028 Lisboa Portugal Ver en el mapa Región Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa Tipo de actividad Research Organisations Contacto administrativo Margarida Pinto Gago (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (1) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo UNIVERSIDAD POMPEU FABRA España Aportación de la UE € 63 000,00 Dirección PLACA DE LA MERCE, 10-12 08002 Barcelona Ver en el mapa Región Este Cataluña Barcelona Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo David Andreu (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
