Objective
Fibrillar deposits of proteins are the hallmark of amyloid diseases, amongst which Alzheimer’s disease stands out as the most widespread neurodegenerative pathology of the brain. Neuronal dysfunction is currently attributed to the interaction of A-beta oligomers with the plasma membrane. Several scenarios have been proposed, but the mechanisms of binding of the oligomers to the cell membrane and their subsequent toxicity is still unclear. The dependence of the proteolytic production of A-beta peptide on the distribution of the amyloid precursor protein (APP) and its proteases on the plasma membrane is also matter of debate.The discrepancies arising from the models proposed may be due to the fact that most of the current research on the molecular mechanisms of Alzheimer’s disease is based on averaged results obtained using bulk methods. In this case, many essential details can be missed. The goal of this project is to provide a better understanding of the pathogenesis of Alzheirmer’s disease by studying the dynamic features of this complex system at a single molecule level. In particular, the immediate aim will be to apply single molecule tracking techniques to characterize the mobility of A-beta oligomers on the plasmamembrane of living neuronal cells, especially with respect to synaptic structures and membrane rafts. In addition, I will study the surface mobility of the transmembrane proteins involved in A-beta production, namely APP, alpha-, beta-, and gamma-secretase. In the light of the influence of cholesterol on A-beta generation, my aim will be to study the dynamic response of these proteins to changes in cell cholesterol levels, and their location inside or outside lipid rafts. Overall, this project represents an innovative approach to understand the basic mechanisms underlying the development of Alzheirmer’s disease and to suggest new strategies for the cure of this pathological condition.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences basic medicine neurology dementia alzheimer
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences biochemistry biomolecules lipids
- medical and health sciences basic medicine pathology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
50019 Sesto-Fiorentino (Fi)
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.