Mechanisms and functions of microtubule plus end tracking proteins in mammalian cells: development of inhibitory strategies

Project Information

MT-TIP INHIBITORS

Grant agreement ID: 253818

Project closed

Start date 1 May 2011

End date 30 April 2013

Funded under

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Total cost € 169 535,20

EU contribution € 169 535,20

Coordinated by

UNIVERSITEIT UTRECHT
Netherlands

Objective

Microtubule plus end tracking proteins are a group of factors that accumulate specifically at the ends of growing microtubules where they control microtubule dynamics and the interactions with different structures, such as mitotic kinetochores, actin cytoskeleton and the cell cortex. The core components of the microtubule plus end tracking machinery are End Binding (EB) proteins, such as EB1, which autonomously track the growing ends of microtubules and recruit to microtubule tips multiple functionally diverse proteins. The aim of this proposal is to use a wide range of microtubule-targeting anti-cancer compounds to systematically probe their effects on the microtubule-EB binding and thus gain insight into the basis of the enigmatic plus end recognition mechanism by the EBs. We also intend to use the detailed knowledge of the mechanisms underlying the interactions of EB proteins with their partners to develop novel reagents to inhibit microtubule plus end tracking of a broad range of proteins and thus probe the general significance of this phenomenon. In addition, we plan to use this knowledge to develop new tools to efficiently visualize growing microtubule ends in different cellular settings.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

• natural sciences › biological sciences › biochemistry › biomolecules › proteins

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Programme(s)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Topic(s)

• FP7-PEOPLE-2009-IIF - Marie Curie Action: "International Incoming Fellowships"

Call for proposal

FP7-PEOPLE-2009-IIF
See other projects for this call

Funding Scheme

MC-IIF - International Incoming Fellowships (IIF)

Coordinator

UNIVERSITEIT UTRECHT

• EU contribution: € 169 535,20
• Address: HEIDELBERGLAAN 8 ; 3584 CS Utrecht ; Netherlands
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data