Objective
Autism (OMIM 209850) and attention deficit/hyperactivity disorder (ADHD) (OMIM 143465) are severe neurodevelopmental disorders with a complex etiology, caused by the interaction of multiple susceptibility genes, environmental and epigenetic factors. Autism and ADHD are the most common developmental disabilities after mental retardation. Different genetic approaches have been used so far to identify the genetic factors underlying complex disorders including linkage studies, association studies, search for cytogenetic abnormalities or Copy Number Variants (CNVs) analysis. The results obtained through these methodologies in recent years indicate that complex diseases such as Autism or ADHD are likely to be caused by a combination of common variants and multiple rare variants at different loci. However, these efforts have resulted in a limited number of significant and replicated findings, that explain only a small part of the genetic contribution to these disorders. The GEVAD proposal (Rare and Common Genetic Variants analysis in ASD and ADHD) aim to identify the genetic factors involved in the susceptibility to Autism and ADHD. The proposal will take advantage of modern high-throughput DNA technologies and expert collaborations to carry out three main studies: 1) Case/Control association studies of SNPs located in miRNA genes and in miRNA-binding motifs of selected candidate genes for Autism and ADHD 2) Replication of rare Copy Number Variants (NRXN1, CNTNAP2,SHANK3, IMMP2L-DOCK4) in autism and exploration of these structural variants as susceptibility factors for ADHD 3) Exome mutation analysis of autistic patients. To our knowledge, this will be the first exome analysis performed in a complex disease. The results emerging from GEVAD will provide new insights into the genetic basis of ASD and ADHD and may point to potential therapeutic targets for these common neuropsychiatric disorders.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences genetics mutation
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
08007 BARCELONA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.