Objective More than 50% of heart failure (HF) patients present without a major deficit of left ventricular (LV) systolic function and are presumed to suffer from diastolic HF (DHF) because diastolic LV distensibility is usually impaired in these patients. The vast majority (~80%) of DHF patients is exposed to metabolic risk factors. The MEDIA consortium therefore investigates:1) how metabolic derangements contribute to DHF; 2) how diagnostic algorithms for DHF can be improved by assessing metabolic risk; 3) how correction of metabolic risk can open new therapeutic perspectives for DHF.Hereto MEDIA will: 1) Expose animal models of DHF to intense metabolic risk in order to accelerate DHF development. 2) Perform mechanistic studies in cardiomyocytes derived from DHF animal models or from DHF patients. Because of the acquired nature of metabolic risk, these studies will focus on posttranslational modifications of proteins and on epigenetic control of hypertrophy development. Their relevance for global LV function will also be appraised; 3) Perform mechanistic studies on myocardial collagen synthesis, which is enhanced by metabolic risk, and execute a phase II trial in DHF with cardiac specific antifibrotic therapy; 4) Explore the use of biomarkers as premorbid identifiers of DHF in existing cohorts of patients exposed to metabolic risk; 5) Prospectively test biomarkers and arterial stiffening, which is accelerated by metabolic risk, for their diagnostic potential in a large DHF cohort; 6) Assess myocardial metabolic substrate preference with modern imaging techniques and improve diastolic LV dysfunction through modified substrate utilization in a phase II trial.Expected results of MEDIA are: 1) Identification of metabolic risk-related mechanisms as therapeutic targets; 2) Improved diagnostic algorithms through inclusion of biomarkers and arterial stiffness tests. 3) Novel treatments consisting of modified myocardial substrate utilization and myocardial antifibrotic therapy. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicinecardiology Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2010.2.4.2-4 - Diastolic heart failure. FP7-HEALTH-2010-single-stage Call for proposal FP7-HEALTH-2010-single-stage See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator STICHTING AMSTERDAM UMC EU contribution No data Address De boelelaan 1117 1081 HV Amsterdam Netherlands See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Research Organisations Administrative Contact Philippe Seignette (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (21) Sort alphabetically Sort by EU Contribution Expand all Collapse all ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Netherlands EU contribution € 497 400,00 Address Dr molewaterplein 40 3015 GD Rotterdam See on map Region West-Nederland Zuid-Holland Groot-Rijnmond Activity type Higher or Secondary Education Establishments Administrative Contact Jacobus Maria Kerkvliet (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data RUHR-UNIVERSITAET BOCHUM Germany EU contribution € 916 945,26 Address Universitaetsstrasse 150 44801 Bochum See on map Region Nordrhein-Westfalen Arnsberg Bochum, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Wolfgang Linke (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CHARITE - UNIVERSITAETSMEDIZIN BERLIN Germany EU contribution € 772 260,00 Address Chariteplatz 1 10117 Berlin See on map Region Berlin Berlin Berlin Activity type Higher or Secondary Education Establishments Administrative Contact Eveline Fraessdorf (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSIDADE DO PORTO Portugal EU contribution € 811 718,88 Address Praca gomes teixeira 4099-002 Porto See on map Region Continente Norte Área Metropolitana do Porto Activity type Higher or Secondary Education Establishments Administrative Contact Manuel Sobral-Torres (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITEIT ANTWERPEN Belgium EU contribution € 554 710,88 Address Prinsstraat 13 2000 Antwerpen See on map Region Vlaams Gewest Prov. Antwerpen Arr. Antwerpen Activity type Higher or Secondary Education Establishments Administrative Contact Anne Adams (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FONDATION TRANSPLANTATION France EU contribution € 975 270,94 Address Rue de la brot 4 21850 St apollinaire See on map Activity type Research Organisations Administrative Contact Stephanie Grojean (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITEIT MAASTRICHT Netherlands EU contribution € 1 053 750,00 Address Minderbroedersberg 4 6200 MD Maastricht See on map Region Zuid-Nederland Limburg (NL) Zuid-Limburg Activity type Higher or Secondary Education Establishments Administrative Contact Rob Vanderzander (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA Spain EU contribution € 788 550,50 Address Avenida de pio xii 55 31008 Pamplona See on map Region Noreste Comunidad Foral de Navarra Navarra Activity type Research Organisations Administrative Contact Andrew Solomon (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITETET I OSLO Norway EU contribution € 500 146,80 Address Problemveien 5-7 0313 Oslo See on map Region Norge Oslo og Viken Oslo Activity type Higher or Secondary Education Establishments Administrative Contact Randi Stene (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data DEBRECENI EGYETEM Hungary EU contribution € 499 783,03 Address Egyetem ter 1 4032 Debrecen See on map Region Alföld és Észak Észak-Alföld Hajdú-Bihar Activity type Higher or Secondary Education Establishments Administrative Contact Zoltán Papp (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DI BRESCIA Italy EU contribution € 496 231,26 Address Piazza mercato 15 25121 Brescia See on map Region Nord-Ovest Lombardia Brescia Activity type Higher or Secondary Education Establishments Administrative Contact Livio Dei Cas (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CARDIFF UNIVERSITY United Kingdom EU contribution € 530 187,40 Address Newport road 30 36 CF24 0DE Cardiff See on map Region Wales East Wales Cardiff and Vale of Glamorgan Activity type Higher or Secondary Education Establishments Administrative Contact Nick Bodycombe (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO Italy EU contribution € 532 471,92 Address Duomo 6 13100 Vercelli See on map Region Nord-Ovest Piemonte Vercelli Activity type Higher or Secondary Education Establishments Administrative Contact Francesco Cellerino (Dr.) Links Contact the organisation Opens in new 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Education Establishments) Administrative Contact Juan Ruiz (Dr.) Links Contact the organisation Opens in new window Total cost No data PLURI BIOTECH LTD Israel EU contribution € 92 955,00 Address Matam industrial park bldg 20 31905 Haifa See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Frida Grynspan (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data OXI GEN LAB SRL Participation ended Italy EU contribution No data Address Via marconi 11/a 25128 Brescia See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Marco Veronesi (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITATSKLINIKUM HEIDELBERG Germany EU contribution € 127 800,00 Address Im neuenheimer feld 672 69120 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Thorsten Brietz (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG Netherlands EU contribution No data Address De boelelaan 1105 1081 HV Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Administrative Contact Philip Seignette (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data STICHTING VU Participation ended Netherlands EU contribution € 1 705 696,00 Address De boelelaan 1105 1081 HV Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Administrative Contact Philip Seignette (Mr.) Links Contact the organisation Opens in new 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