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Infectious triggers of chronic autoimmunity

Ziel

This proposal builds on existing expertise and collaborations of a multidisciplinary Consortium of basic scientists and clinical investigators each of whom has made a substantial individual contribution to understanding the links between infection and autoimmunity. The aim of the INTRICATE Consortium is to prosecute a programme of Translational Research that deliniates the role of infection in the induction and perpetuation of severe systemic autoimmune disease with the ultimate object of identifying new therapeutic strategies based on knowledge of pathogenesis.
Our strategy will systematically analyse the complex and diverse processes involved in a “model” human disease: - Anti-neutrophil cytoplasmic antibody (ANCA) associated systemic vasculitis (AAV). AAV is ideally suited because it is known to be caused by autoantibodies of defined specificity and second because it is strongly linked to infection to infection. INTRICATE will use mouse models to answer the specific question whether infection with clinically relevant bacteria induces autoimmune disease in transgenic mice that express the human autoantigen. The use of novel high-throughput antigen array technology in well-characterized patient cohorts and analysis of microbial and host specific mechanisms combined with genome wide association study (GWAS) will determine whether dysbiosis or infection with specific microorganisms triggers the induction or re-activation of AAV. Unraveling the pathogenic processes that are responsible for this chronic autoimmune disease and the knowledge gained will lead to the development of novel preventive and therapeutic strategies.

Wissenschaftliches Gebiet

Programm/Programme

Thema/Themen

Aufforderung zur Vorschlagseinreichung

FP7-HEALTH-2010-single-stage
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

CP-FP - Small or medium-scale focused research project

Koordinator

MEDIZINISCHE UNIVERSITAET WIEN
EU-Beitrag
€ 954 078,00
Adresse
SPITALGASSE 23
1090 Wien
Österreich

Auf der Karte ansehen
Region
Ostösterreich Wien Wien
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Dontscho Kerjaschki (Prof.)
Links
Gesamtkosten
Keine Daten

Beteiligte (11)

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Letzte Aktualisierung: 26 Mai 2017

Mein Booklet

Permalink: https://cordis.europa.eu/project/id/261382/de

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