Objective
The identification of the extracellular calcium sensing receptor (CaSR) was a crucial step in understanding nutrient sensing in mammals. In mammalian organisms the CaSR has multiple roles: besides calcium homeostasis, it is involved in protection against osteoporosis, blood vessel calcification, prevention against colorectal cancer, is involved in metastasis of breast and prostate cancer cells to bone. The proposed ITN will perform basic and multidisciplinary investigations into the role of the CaSR and will provide experimental data for computational modelling. It will use holistic approaches of systems biology to gain knowledge on mechanisms of CaSR function.
We will use intersectoral expertise in revealing the significance of CaSR signalling in cancer, and cardiovascular disease.
The purpose of this ITN is to:
• Educate and train Early Stage Researchers to become excellent scientists, enable them to gain a holistic view of their specific research area, prepare them for the challenges of working in a highly competitive environment, be it in Academia or in Industry.
• Generate a systems biology model for CaSR-dependent signalling in order to find innovative therapeutic approaches and interventions for the natural and synthetic ligands of the CaSR.
• Establish long lasting interdisciplinary and intersectoral cooperation among basic, clinical and applied researchers, working on the CaSR to strengthen the European Research Area.
Being in a research environment that examines the role of one single molecule in many different tissues (e.g. kidney, intestine, blood vessels) and pathologies (cancer and vascular calcification), will increase the awareness of the young researchers for a holistic approach in understanding CaSR-related pathophysiology. Continuous comparison of the function of the CaSR in systems studied by their fellow ESRs, will sensitize the young researchers for the complexities of biomedical research and advantages of multidisciplinarity.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology prostate cancer
- medical and health sciences basic medicine physiology pathophysiology
- medical and health sciences clinical medicine oncology colorectal cancer
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- medical and health sciences basic medicine physiology homeostasis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-ITN
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1090 Wien
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.