Objective
The aim of my project is to test two novel experimental radiotherapies which potentially can improve the quality life in patients with malignant brain tumours or with multiple brain metastases. Both methods are being developed at international synchrotron facilities. One of the techniques, microbeam radiation therapy (MRT), is already being studied by several groups and my work is focused on the assessment of adverse effects like memory deficits and bystander effects. Concept and equipment for the second technique, pencilbeam radiotherapy, have only recently been developed at the ESRF in France. Our team will be the first to obtain biological data and assist in developing the technique to a point where a valid assessment can be made regarding its feasibility for therapeutic approach in human patients. All tests will be conducted in well-validated small animal models for an advanced, highly malignant primary brain tumour and for multiple brain metastases from a mamma carcinoma.
We will study the acute effects of the radiotherapy in short-term experiments as well as generate survival curves and behavioural data in long-term survivors. In order to document the efficacy of the experimental therapy we will also use a high-resolution synchrotron-based X-ray imaging technique, in which small groups of cells loaded with an X-ray opaque marker can be detected. The applicant for this project is one of the four patent holders for this method.
The Marie Curie Reintegration Grant would help me to establish my own work group in Freiburg, thereby combining my previous research experience with the interests of the Department of Stereotactic Neurosurgery and the Laboratory of Molecular Neurosurgery, where I have been working since September 2009. The project also integrates research facilities in three European countries (Germany, France and Italy) as well as a collaboration with a radiobiology team from McMaster University in Hamilton, Canada.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-RG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
79106 Freiburg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.