Cel Higher plants and animals establish elaborate body plans with one end of the organism being different from another. Polar organisation is also of fundamental importance at the single-cell level, because mutations affecting cell polarity may cause severe body deformations. Hence, cell polarity is a central theme of biological research and much progress has been made towards our understanding of cellular polarisation along the shoot-root (apical-basal) axis of plants. By contrast, how polarity is established towards inner and outer lateral membranes of plant cells remains unresolved. Here, I propose to identify components controlling lateral cell polarity, employing the root epidermis of the genetic model plant Arabidopsis as an excellent system readily accessible for cell biological analyses. Root epidermal cells display polar nuclear movement towards the inner lateral membrane and proteins located at the outer lateral membrane. We will employ tools for visualization of these polar events that will enable us to A) perform forward genetic screens to discover signals and requirements for polar nuclear movement and outer lateral membrane polarity, B) apply forward and reverse genetics to unravel cytoskeletal requirements of lateral polarisation, C) employ live-cell imaging to reveal the dynamics of polarising events and D) combine genetic and cellular analyses with regulators of apical-basal polarity. Our work will uncover how a single cell separates and integrates polarising events along diverse axes. The proposed research is groundbreaking, as it will lay foundations for an understanding of lateral polarity establishment in plants. Finally, it will aid our understanding of how mechanisms underlying polarising events evolved differently in diverse multicellular organisms. Dziedzina nauki natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencescell biologycell polaritynatural sciencesbiological sciencesgeneticsmutation Program(-y) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) ERC-SG-LS3 - ERC Starting Grant - Cellular and Developmental Biology Zaproszenie do składania wniosków ERC-2010-StG_20091118 Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-SG - ERC Starting Grant Instytucja przyjmująca UNIVERSITAET POTSDAM Wkład UE € 562 491,52 Adres AM NEUEN PALAIS 10 14469 Potsdam Niemcy Zobacz na mapie Region Brandenburg Brandenburg Potsdam Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Adriana Wipperling (Dr.) Kierownik naukowy Markus Grebe (Prof.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Beneficjenci (2) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko UNIVERSITAET POTSDAM Niemcy Wkład UE € 562 491,52 Adres AM NEUEN PALAIS 10 14469 Potsdam Zobacz na mapie Region Brandenburg Brandenburg Potsdam Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Adriana Wipperling (Dr.) Kierownik naukowy Markus Grebe (Prof.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych UMEA UNIVERSITET Szwecja Wkład UE € 800 960,48 Adres UNIVERSITETOMRADET 901 87 Umea Zobacz na mapie Region Norra Sverige Övre Norrland Västerbottens län Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Ylva Johansson (Ms.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
