Mathematical modeling of anaesthetic action

Objetivo

General anaesthesia is an important method in today's hospital practice and especially in surgery. To supervise the depth of anaesthesia during surgery, the anaesthesist applies electroencephalography (EEG) and monitors the brain activity of the subject on the scalp. The applied monitoring machine calculates the change of the power spectrum of the brain signals to indicate the anaesthetic depth. This procedure is based on the finding that the concentration increase of the anaesthetic drug changes the EEG-power spectrum in a significant way. Although this procedure is applied world-wide, the underlying neural mechanism of the spectrum change is still unknown. The project aims to elucidate the underlying neural mechanism by a detailed investigating a mathematical model of neural populations.
The investigation is based on analytical calculations in a neural population model of the cortex involving intrinsic neural properties of brain areas and feedback loops to other areas, such as the loop between the cortex and the thalamus. Currently, there are two proposed mechanisms for the charactertisic change of the power spectrum: a highly nonlinear jump in the activation (so-called phase transition) and a linear behavior. The project mainly focusses on the nonlinear jump to finally rule it out or support it. A subsequent comparison to previous experimenta results aims to fit the physiological parameters. Since the cortex population is embedded into a network of other cortical areas and the thalamus, the corresponding analytical investigations takes into account external stochastic (from other brain areas) and time-periodic (thalamic) forces. To this end it is necessary to develop several novel nonlinear analysis technique of neural populations to derive the power spectrum close to the phase transition and conditions for physiological parameters.

Ámbito científico

Régimen de financiación

ERC-SG - ERC Starting Grant

Institución de acogida

INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET AUTOMATIQUE

Aportación de la UE

€ 856 500,00

Dirección

DOMAINE DE VOLUCEAU ROCQUENCOURT
78153 Le Chesnay Cedex
Francia

Región

Ile-de-France Ile-de-France Yvelines

Tipo de actividad

Research Organisations

Investigador principal

Axel Hutt (Dr.)

Contacto administrativo

Armelle Demange (Ms.)

Enlaces

Contactar con la organización Sitio web

Coste total

Sin datos

Beneficiarios (1)