Objetivo The proposal's overall aim is to improve cervical cancer prevention programs for HIV–infected women in Africa, by evaluating the effectiveness and cost-effectiveness of alternative screening strategies, and by developing algorithms leading to earlier detection and management of cervical cancer in these high-risk populations.The proposal's hypotheses are that: i) the use of simplified point of care diagnostic tests to detect high-risk (HR) HPV DNA , never before evaluated in Africa, alone or combination with other tests in various triage strategies has the potential to improve the coverage of cervical cancer screening in high-risk populations, and that it will prove a cost-effective cervical cancer prevention intervention in the long term; and ii) immune restoration and control of HIV replication through highly active antiretroviral therapy (HAART) or HAART initiation improves clearance of HPV infection among high-risk (HR)-HPV infected women, therefore slowing the development or progression of cervical precursor lesions. These findings may suggest that varying strategies or frequencies of screening may be required for women on HAART or not.The study will enroll 1200 HIV positive women (half on HAART or about to start HAART; and half with high CD4 count>350) in Burkina Faso and South Africa in a cross-sectional evaluation of cervical cancer screening strategies, from which about 1100 HIV-infected women without CIN2+ will be followed at one year to detect incident CIN2+ and persistence, incidence and clearance of HR HPV. A costing and modelling studies will determine the cost-effectiveness of triage strategies targeting HIV+ women. Ámbito científico natural sciencesbiological sciencesgeneticsDNAmedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVmedical and health sciencesclinical medicineoncologycervical cancermedical and health scienceshealth sciencesinfectious diseasesDNA viruses Programa(s) FP7-HEALTH - Specific Programme "Cooperation": Health Tema(s) HEALTH.2010.2.4.1-4 - Infectious agents and cancer in Africa Convocatoria de propuestas FP7-AFRICA-2010 Consulte otros proyectos de esta convocatoria Régimen de financiación CP-FP-SICA - Small/medium-scale focused research project for specific cooperation actions dedicated to international cooperation partner countries(SICA) Coordinador LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER Aportación de la UE € 694 994,00 Dirección KEPPEL STREET WC1E 7HT London Reino Unido Ver en el mapa Región London Inner London — West Camden and City of London Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Frankie Liew (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (3) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo UNIVERSITY OF THE WITWATERSRAND JOHANNESBURG Sudáfrica Aportación de la UE € 1 237 360,00 Dirección JAN SMUTS AVENUE 1 2001 Johannesburg Ver en el mapa Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Violet Parker (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos CENTRE DE RECHERCHE INTERNATIONALE POUR LA SANTE Burkina Faso Aportación de la UE € 621 201,00 Dirección Avenue de l'Universite 221 Secteur 13 Zogona 09 Ouagadougou Ver en el mapa Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Aminata Karambiri (Ms.) Enlaces Contactar con la organización Opens in new window Coste total Sin datos UNIVERSITE MONTPELLIER I Francia Aportación de la UE € 446 445,00 Dirección BOULEVARD HENRI IV 5 34967 MONTPELLIER Ver en el mapa Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Cara Chan Manville (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos