Objective
REM sleep behavior disorders (RBD) are violent dream-enactments caused by loss of normal muscle atonia during REM sleep. RBD are idiopathic or associated with neurological diseases (parkinsonism, narcolepsy) and represents an exceptional window on dream content and motor control during REM sleep. The characteristics of the movements during RBD have been poorly studied. In patients with Parkinson’s disease, we recently found that movements were faster, and speech was more intelligible during RBD than during wakefulness. The disappearance of parkinsonism during REM sleep suggests a transient ‘levodopa-like’ reestablishment of the basal ganglia loop. Alternatively, the jerky movements could be the expression of the primary motor cortex, relieved from the filtering, smoothing control of the basal ganglia. To support this hypothesis, using questionnaire and video-polysomnography, we will measure (i) if the head, mouth, arms and hands are more used than the legs during the RBD, as they have a larger cortical representation ii) examine the synchronization between the direction of eye movement (the major characteristics of REM sleep) with other movements during RBD in relation to dream imagery in REM sleep. To further understand the role of REM sleep-dependent procedural learning, we will also analyze in RBD patients if a specific procedural task is replayed during REM and the context of the replay. The first, precise description of movements during RBD and their synchronization with rapid eye movement real-time correlated with visual dream imagery would bring important information to recognize them in complex clinical cases, to infer their source, and to understand why parkinsonism disappears during RBD. Finally, the exploration « in live » of the potential replay of a procedural learned task in RBD patients represents a new approach that could carry some evidence supporting the role of REM sleep in procedural learning.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine psychiatry sleep disorders
- medical and health sciences basic medicine neurology parkinson
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-RG
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75654 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.